Browsing by Author "Nicklin, P."

Now showing items 1-3 of 3

    • Bidirectional transport of amino acids regulates mTOR and autophagy 

      Nicklin, P.; Bergman, P.; Zhang, B.; Triantafellow, E.; Wang, H.; Nyfeler, B.; Yang, H.; Hild, M.; Kung, C.; Wilson, C.; Myer, V.E.; MacKeigan, J.P.; Porter, J.A.; Wang, Y.K.; Cantley, L.C.; Finan, P.M.; Murphy, L.O. (2009-02-06)
      Amino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase which regulates protein translation, cell growth, and autophagy. Cell surface transporters that allow amino acids to enter the cell ...

    • Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension 

      Soon, E.; Holmes, A.M.; Treacy, C.M.; Doughty, N.J.; Southgate, L.; MacHado, R.D.; Trembath, R.C.; Jennings, S.; Barker, L.; Nicklin, P.; Walker, C.; Budd, D.C.; Pepke-Zaba, J.; Morrell, N.W. (2010-08-31)
      Background: Inflammation is a feature of pulmonary arterial hypertension (PAH), and increased circulating levels of cytokines are reported in patients with PAH. However, to date, no information exists on the significance ...

    • Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions 

      Stringer, R.A.; Strain-Damerell, C.; Nicklin, P.; Houston, J.B. (2009-05-01)
      The aim of this study was to explore the potential of recombinant cytochrome P450 (P450) enzymes for human metabolic clearance prediction. The relative abundance and relative activity approaches were compared as methods ...