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Browsing by Author "Nicklin, P.L."
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Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance
Stringer, R.; Nicklin, P.L.; Houston, J.B. (2008-10-01)A total of 110 drugs, selected to cover a range of physicochemical and pharmacokinetic properties, were used to explore standard approaches to the prediction of in vivo metabolic clearance using drug-depletion profiles ...