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Browsing by Author "Nikiphorou, Elena"
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Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery : Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds
Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick; Gough, Andrew; Devlin, Joe; Emery, Paul; Waterhouse, Lynn; James, David; Tate, Helen; Boys, Cathy; Williams, Peter; White, Dora; Dart, Helen; Winfield, John; Seymour, Annie; Williams, Richard; Blunn, Karina; McDowell, Jackie; Prouse, Peter; Andrews, Sheryl; Wilson, Deborah; Magliano, Malgorzata; Perks, Ursula; Coulson, Amanda; Hassle, Andrew; Kirwan, Michele; Leone, Francesca; Dunne, Ciaran; Hawley, Lindsey; Creamer, Paul; Taylor, Julie; Wilmott, Wendy; Knights, Sally; Rowland-Axe, Rebecca; Green, Sandra; Simmons, Dawn; David, Joel; Cox, Maureen; Bukhari, Marwan; Evans, Bronwen; Batley, Michael; Oram, Catherine; ERAS and ERAN (2016-11-10)Objectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores ... -
The association between social deprivation and disease activity in rheumatoid arthritis: A systematic literature review
Dey, Mrinalini; Busby, Amanda; Ewell, Helen; Lempp, Heidi; Pratt, Arthur; Young, Adam; Isaacs, John; Nikiphorou, Elena (2022-04-21)Physical and mental illnesses are driven by ethnicity, social, environmental and economic determinants. Novel theoretical frameworks in rheumatoid arthritis (RA) focus on links and adverse interactions between and within ... -
Can Early, Clinically Significant Radiographic Progression In The First Year Of Disease Predict Orthopaedic Surgery In Patients With Rheumatoid Arthritis?
Carpenter, Lewis; Jayakumar, Keeranur; Nikiphorou, Elena; Norton, Sam; Dixey, Josh; Young, Adam (2014-04)BACKGROUND: Orthopaedic intervention is an important outcome in Rheumatoid Arthritis (RA). The use of radiographic data in the early stages of the disease and its importance in determining future RA related outcomes is ... -
Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged : results from two UK inception cohorts
Nikiphorou, Elena; Carpenter, Lewis; Morris, Stephen; MacGregor, Alex J.; Dixey, Josh; Kiely, P.; Norton, S.; James, David W.; Walsh, D.; Young, Adam (2014-04-28)To assess whether there have been any secular changes in orthopedic interventions in patients with rheumatoid arthritis (RA) since 1986, as examined in 2 early rheumatoid arthritis (RA) inception cohorts with up to 25 years ... -
Have Radiographic Progression Rates in Early Rheumatoid Arthritis Changed? : A Systematic Review and Meta-analysis of Long-term Cohorts
Carpenter, Lewis; Nikiphorou, Elena; Sharpe, Rachel; Norton, Sam; Rennie, Kirsten; Bunn, Frances; Scott, David; Dixey, Josh; Young, Adam (2016-06-01)The objectives of this systematic review are to evaluate firstly, all published data on baseline and annual progression rates of radiographic damage from all longitudinal observational cohorts, and secondly, the association ... -
Importance of registries in informing clinical practice for arthritis
Carpenter, Lewis; Nikiphorou, Elena; Young, Adam (2013-11)The gold standard in research for evidence that underlies clinical practice is the randomized controlled trial. In recent years it has been accepted that observational studies, which include disease and drug registries and ... -
Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis
Gwinnutt, James M.; Norton, Sam; Hyrich, Kimme L.; Lunt, Mark; Combe, Bernard; Rincheval, Nathalie; Ruyssen‐Witrand, Adeline; Fautrel, Bruno; McWilliams, Daniel F.; Walsh, David A.; Nikiphorou, Elena; Kiely, Patrick D. W.; Young, Adam; Chipping, Jacqueline R.; MacGregor, Alex; Verstappen, Suzanne M. M. (2023-05-30)Objective: To investigate how social support, financial status, and lifestyle influence the development of excess disability in rheumatoid arthritis (RA). Methods: Data were obtained from the Étude et Suivi des Polyarthrites ... -
Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts
Kiely, Patrick; Busby, Amanda; Nikiphorou, Elena; Sullivan, Keith; Walsh, David; Creamer, Paul; Dixey, Josh; Young, Keith (2019-05-05)Objectives To assess predictive factors for rheumatoid arthritis interstitial lung disease (RA-ILD) in two early RA inception cohorts with a focus on methotrexate (MTX) exposure. Design Multicenter prospective early RA ... -
Large joints are progressively involved in rheumatoid arthritis irrespective of rheumatoid factor status—results from the early rheumatoid arthritis study
Zhao, Sizheng Steven; Nikiphorou, Elena; Young, Adam; Kiely, Patrick D. W. (2021-08-16)This study aimed to examine the progression of large joint involvement from early to established RA in terms of range of movement (ROM) and time to joint surgery, according to the presence of rheumatoid factor (RF). We ... -
Osteoporotic fracture and post operative clinical and cost outcomes in rheumatoid arthritis (RA) : results from two UK inception cohorts
Nikiphorou, Elena; Carpenter, Lewis; Dixey, Josh; Williams, P.; Kiely, P.; Walsh, D; Williams, Richard; Young, Adam (2013-10)379: The risk of osteoporotic fracture is known to be high in RA. Yet less is known about RA related predictive factors for this complication & its associated economic burden -
Personalised care packages for people with rheumatoid arthritis: a mixed-methods study
Dey, Mrinalini; Busby, Amanda; Isaacs, John; Pratt, Arthur; Ndosi, Mwidimi; Young, Adam; Lempp, Heidi; Nikiphorou, Elena (2024-01-08)Objectives Disease management in rheumatoid arthritis (RA) requires holistic assessment. We aimed to design personalised care packages suitable for people with RA. Methods This study was conducted using a mixed-methods ... -
Predictors of poor function in RA based on two prospective UK inception cohorts. Do comorbidities matter?
Busby, Amanda; Wason, James; Pratt, Arthur; Young, Adam; Isaacs, John; Nikiphorou, Elena (2021-07-24)Objectives. Evidence suggests that factors beyond disease activity associate with functional disability in RA. The primary study objective was to explore associations between comorbidities, sociodemographic factors and ... -
Reductions in Radiographic Progression in Early Rheumatoid Arthritis Over Twenty-Five Years: : Changing Contribution From Rheumatoid Factor in Two Multicenter UK Inception Cohorts
Carpenter, Lewis; Norton, Sam; Nikiphorou, Elena; Jayakumar, Keeranur; McWilliams, Daniel F.; Rennie, Kirsten L.; Dixey, Josh; Kiely, Patrick; Walsh, David Andrew; Young, Adam; on behalf of the Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network (2017-11-28)Objective: To assess the 5-year progression of erosions and joint space narrowing (JSN) and their associations with rheumatoid factor (RF) status in 2 large, multicenter, early rheumatoid arthritis cohorts, spanning 25 ... -
Remission vs low disease activity: function, quality of life and structural outcomes in the Early Rheumatoid Arthritis Study and Network
Nikiphorou, Elena; Norton, Sam; Carpenter, Lewis; Welsh, David; Creamer, Paul; Dixey, Josh; Young, Adam; Kiely, Patrick (2019-10-03)Objectives To examine associations between function, quality of life and structural outcomes in patients achieving remission vs low disease activity in early RA. Methods Demographic, clinical and radiographic variables ... -
Rheumatoid Arthritis
Nikiphorou, Elena; Young, Adam (Oxford University Press (OUP), 2015-06-25) -
The role of comorbidities alongside patient and disease characteristics in long-term disease activity in RA using UK inception cohort data
Busby, Amanda; Wason, James; Pratt, Arthur; Young, Adam; Isaacs, John; Nikiphorou, Elena (2022-11-30)Objectives Control of disease activity in RA is a crucial part of its management to prevent long-term joint damage and disability. This study aimed to identify early predictors of poor disease activity at 5 and 10 years, ... -
Secular Changes in Clinical Features at Presentation of Rheumatoid Arthritis : Increase in Comorbidity But Improved Inflammatory States
Nikiphorou, Elena; Norton, Sam; Carpenter, Lewis; Dixey, Josh; Andrew Walsh, David; Kiely, Patrick; Young, Adam; on behalf of the Early Rheumatoid Arthritis Study and the Early Rheumatoid Arthritis Network Cohorts (2017-01-31)Objective: To examine secular trends in demographics, clinical manifestations, and comorbidity on first presentation of rheumatoid arthritis (RA) prior to disease-modifying antirheumatic drug treatment. Methods: A total ... -
Secular changes in the progression of clinical markers and patient-reported outcomes in early rheumatoid arthritis
Carpenter, Lewis; Nikiphorou, Elena; Kiely, Patrick D W; Walsh, David A; Young, Adam; Norton, Sam (2020-01-03)OBJECTIVES: To examine secular trends in the progression of clinical and patient-reported outcomes in early RA. METHODS: A total of 2701 patients recruited to the Early Rheumatoid Arthritis Study or Early Rheumatoid Arthritis ... -
The use and context of the term “multimorbidity” in rheumatoid arthritis: a systematic literature review
Dey, Mrinalini; Busby, Amanda; Ewell, Helen; Pratt, Arthur; Young, Adam; Isaacs, John; Nikiphorou, Elena (2021-04-23)This systematic literature review aimed to analyse terms describing coexisting conditions in the RA literature, informing the need for an operationalized definition of multimorbidity. Articles discussing RA with multimorbidity, ... -
Validation of methods for converting the original Disease Activity Score (DAS) to the DAS28
Carpenter, Lewis; Norton, Sam; Nikiphorou, Elena; Kiely, Patrick; Walsh, David; Dixey, Josh; Young, Keith (2018-12-01)The Disease Activity Score (DAS) is integral in tailoring the clinical management of rheumatoid arthritis (RA) patients and is an important measure in clinical research. Different versions have been developed over the years ...