- UHRA Home
- Browsing by Author
Browsing by Author "Nikolic, M."
Now showing items 1-6 of 6
-
Fukutin-related protein alters the deposition of laminin in the eye and brain
Ackroyd, M.R.; Whitmore, C.; Prior, S.; Kaluarachchi, M.; Nikolic, M.; Mayer, U.; Muntoni, F.; Brown, S.C. (2011-09-07)Mutations in fukutin-related protein (FKRP) are responsible for acommongroup of muscular dystrophies ranging from adult onset limb girdle muscular dystrophies to severe congenital forms with associated structural brain ... -
The molecular mystery of neuronal migration : FAK and Cdk5
Nikolic, M. (2004)The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still ... -
Pak1 and its T212 phosphorylated form accumulate in neurones and epithelial cells of the developing rodent
Zhong, J.L.; Banerjee, M.D.; Nikolic, M. (2003-09-01)The serine/threonine kinase Pak1 is a target of the RhoGTPases Rac and Cdc42 and an important regulator of cell morphology and migration. Recent work from several laboratories has indicated that Pak1 controls microtubule ... -
Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis
Banerjee, M.; Worth, D.; Prowse, David M.; Nikolic, M. (2002-07-23)The Pak kinases are targets of the Rho GTPases Rac and Cdc42, which regulate cell shape and motility [1-5]. It is increasingly apparent that part of this function is due to the effect Pak kinases have on microtubule ... -
Phosphorylation of Pak1 by the p35/Cdk5 Kinase Affects Neuronal Morphology
Rashid, T.; Banerjee, M.; Nikolic, M. (2001-12-28)The small GTPase Rac and its effectors, the Pak1 and p35/Cdk5 kinases, have been assigned important roles in regulating cytoskeletal dynamics in neurons. Our previous work revealed that the neuronal p35/Cdk5 kinase associates ... -
Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition
Engmann, O.; Hortobágyi, T.; Pidsley, R.; Troakes, C.; Bernstein, H.-G.; Kreutz, M.R.; Mill, J.; Nikolic, M.; Giese, K.P. (2011-08)Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most abundant. The functions of cyclin-dependent kinase 5 signalling in cognition and cognitive disorders remains unclear. Here, we show that ...