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Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis
Dexter, Alex; Steven, Rory T; Patel, Aateka; Dailey, Lea Ann; Taylor, Adam J; Ball, Doug; Klapwijk, Jan; Forbes, Ben; Page, Clive P; Bunch, Josephine (2019-12)Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry ...