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Browsing by Author "Parsons, M."
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Arachidonic Acid Mediates Non-Capacitative Calcium Entry Evoked by CB1-Cannabinoid Receptor Activation in DDT1MF-2 Smooth Muscle Cells
Demuth, D.G.; Gkoumassi, E.; Droege, M.J.; Dekkers, B.G.J.; Esselink, H.J.; Vanree, R.M.; Parsons, M.; Zaagsma, J.; Molleman, A.; Nelemans, S.A. (2005)Cannabinoid CB1-receptor stimulation in DDT1 MF-2 smooth muscle cells induces a rise in [Ca2+]i, which is dependent on extracellular Ca2+ and modulated by thapsigargin-sensitive stores, suggesting capacitative Ca2+ entry ... -
Characterisation of nicotine receptors on human peripheral blood mononuclear cells (PBMC)
Wongsriraksa, A.; Parsons, M.; Whelan, C.J. (2009)Aim and objective: The aim of the work was to characterise the nAChRs on human PBMC. Method: PBMC were isolated from human blood buffy coats provided by the blood transfusion service and were used for radioligand binding ... -
The effects of 9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
Jamontt, J.M.; Molleman, A.; Pertwee, R.G.; Parsons, M. (2010)Background and purpose : Cannabis is taken as self-medication by patients with inflammatory bowel disease for symptomatic relief. Cannabinoid receptor agonists decrease inflammation in animal models of colitis, but their ... -
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation
Makwana, R.; Molleman, A.; Parsons, M. (2010)Background and purpose: Cannabinoid receptor agonists reduce intestinal propulsion in rodents through the CB1 receptor. In addition to its antagonistic activity at this receptor, rimonabant (N-(piperidino)-5-(4-chlorophe ... -
Histamine and its receptors
Parsons, M.; Ganellin, C.R. (2006)This article reviews the development of our knowledge of the actions of histamine which have taken place during the course of the 20th century. Histamine has been shown to have a key physiological role in the control of ... -
Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus
Forrest, A.; Huizinga, J.D.; Wang, X.Y.; Liu, L.W.C.; Parsons, M. (2008) -
Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids
Ihenetu, K.; Molleman, A.; Parsons, M.; Whelan, C.J. (2003) -
Investigation of nicotine binding to THP-1 cells : evidence for a non-cholinergic binding site
Morgan, D.; Parsons, M.; Whelan, C.J. (2001)Nicotine is known to modulate immune function, but reports have produced conflicting evidence as to whether nicotinic acetylcholine (nACh) receptors are responsible for these effects. This study was designed to examine the ... -
Modulation of the release of endogenous adenosine by cannabinoids in the myenteric preparation of the guinea-pig plexus-longitudinal muscle ileum
Begg, M.; Dale, N.; Llaudet, E.; Molleman, A.; Parsons, M. (2002) -
Modulation of the release of endogenous gamma-aminobutyric acid by cannabinoids in the guinea pig ileum
Begg, M.; Molleman, A.; Parsons, M. (2002) -
A new era for gastrointestinal research - novel therapeutic targets for drug development
Parsons, M.; Whittle, B.J. (2004) -
Nicotinic acetylcholine receptor subunits and receptor activity in the epithelial cell line HT29
Summers, A.E.; Whelan, C.J.; Parsons, M. (2003) -
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells
Ihenetu, K.; Molleman, A.; Parsons, M.; Whelan, C.J. (2003) -
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation
Makwana, R.; Molleman, A.; Parsons, M. (2010)Background and purpose: Cannabinoid effects on intestinal transit are commonly evaluated in rats. We characterized the cannabinoid receptors mediating the inhibitory effect of 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hyd ... -
The responses to manipulation of extracellular and intracellular calcium are altered in the streptozotocin-diabetic rat colon and ileum
Forrest, A.; Molleman, A.; Parsons, M. (2005) -
The short circuit of the ileum but not the colon is altered in the streptozotocin diabetic rat
Forrest, A.; Makwana, R.; Parsons, M. (2006) -
Signal transduction of cannabinoid CB1 receptors in a smooth muscle cell line
Begg, M.; Baydoun, A. R.; Parsons, M.; Molleman, A. (2001) -
Streptozotocin-induced diabetes modulates presynaptic and postsynaptic function in the rat ileum
Talubmook, C.; Forrest, A.; Parsons, M. (2003)