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Browsing by Author "Patidar, Ashish"
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Beta-glucans in advanced CKD : role in endotoxaemia and inflammation
Wong, Jonathan; Zhang, Yonglong; Swift, Oscar; Finkelman, Malcolm; Patidar, Ashish; Ramanarayanan, Sivaramakrishnan; Vilar, Enric; Farrington, Ken (2020-04-06)BACKGROUND/AIMS: (1-3)-β-D glucans (BG) are cellular components of yeasts and fungi. Elevated blood levels may be an adjunct in diagnosing invasive fungal infection, though can be high in dialysis patients without fungaemia. ... -
Diabetes confers in vitro calcific potential on serum which associates with in-vivo vascular calcification
Patidar, Ashish; Singh, Dhruv; Thakur, Shori; Winocour, Peter; Farrington, Kenneth; Baydoun, Anwar (2017-05-09)Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum, enabling it to induce ... -
Human uraemic serum displays calcific potential in vitro that increases with advancing chronic kidney disease
Patidar, Ashish; Singh, Dhruv; Winocour, Peter; Farrington, Ken; Baydoun, A. R. (2013-03)Vascular calcification strongly correlates with declining renal function and contributes to the high morbidity and mortality of patients with chronic kidney disease (CKD). It is closely regulated by circulating factors but ... -
Is Endotoxemia in Stable Hemodialysis Patients an Artefact? : Limitations of the Limulus Amebocyte Lysate Assay and Role of (1→3)-β-D Glucan
Wong, Jonathan; Zhang, Yonglong; Patidar, Ashish; Vilar, Enric; Finkelman, Malcolm; Farrington, Kenneth (2016-10-20)BACKGROUND: Elevated blood endotoxin levels are frequently reported in the dialysis population and are strongly linked with inflammation, a major predictor of mortality. Virtually all studies have employed the Limulus ... -
Uremic serum-induced calcification of human aortic smooth muscle cells is a regulated process involving Klotho and RUNX2
Patidar, Ashish; Singh, Dhruv K; Thakur, Shori; Farrington, Ken; Baydoun, Anwar R (2019-10-11)Vascular calcification (VC) is common in subjects with chronic kidney disease (CKD) and is associated with increased cardiovascular risk. It is an active process involving transdifferentiation of arterial smooth muscle ...