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Browsing by Author "Pecoraro, Beatrice"
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Investigation on Quantitative Structure-Activity Relationships of 1,3,4 Oxadiazole Derivatives as Potential Telomerase Inhibitors
Tutone, Marco; Pecoraro, Beatrice; Almerico, Anna Maria (2018-07-23)A series of 1,3,4-oxadiazole derivatives with significant broad-spectrum anticancer activity against different cell lines, and demonstrated telomerase inhibition, was subjected to Quantitative Structure-Activity Relationships ... -
Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies
Pecoraro, Beatrice; Tutone, Marco; Hoffman, Ewelina; Hutter, Victoria; Almerico, Anna Maria; Traynor, Matthew (2019-05-28)The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters. ... -
A quantitative structure-permeability relationship model for split-thickness skin absorption, reasoning for the choice of the database.
Pecoraro, Beatrice; Hoffman, Ewelina; Hutter, Victoria; Traynor, Matthew (2018-06-20)The skin is the largest organ in the human body, protecting the body from xenobiotic invasion (1). Local and systemic drugs may also be administered through the skin, therefore the need to measure the permeability of the ...