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Browsing by Author "Perez Diaz, Noelia"
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Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (MDPI Multidisciplinary Digital Publishing Institute, 2022-05-01)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (2021-03-19)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepan-cies in understanding the complex role ... -
The Effects of PPARβ/δ Ligands on Lung Inflammation and Vascular Reactivity
Perez Diaz, Noelia (2020-01-13)The peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a transcription factor ubiquitously expressed in cells, although more highly active in skeletal muscle, arteries and endothelium. Signalling via PPARβ/δ ... -
Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Zloh, Mire; Perez Diaz, Noelia; Tang, Leslie; Patel, Pryank; MacKenzie, Louise Susan (2016-02-01)Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen ... -
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.
Perez Diaz, Noelia; Zloh, Mire; Patel, Pryank; MacKenzie, Louise Susan (2016-01-01)Prostacyclin (PGI2) is a key mediator involved in cardiovascular homeostasis, acting predominantly on two receptor types; cell surface IP receptor and cytosolic peroxisome proliferator activated receptor (PPAR) β/δ. Having ... -
Linking Induction and Transrepression of PPARβ/δ with Cellular Function
Perez Diaz, Noelia; MacKenzie, Louise Susan (2015-01-26)Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear hormone receptor superfamily. PPARβ/δ is ubiquitously expressed and has a central role in homeostasis, ... -
The PPARβ/δ agonist GW0742 prevents LPS-induced nitrite production in rat parenchyma but not in aorta or pulmonary arteries
Perez Diaz, Noelia; Barakat, Jehan; Perez-Vizcaino, Fernando; Moreno, Laura; MacKenzie, Louise Susan (2014-12)Peroxisome Proliferator activated receptors (PPARs) are therapeutic targets in the treatment of inflammatory lung disease. The PPARβ/δ agonist GW0742 has potent anti-inflammatory effects in the vasculature (Kapoor et al ...