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Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils
Pettipher, Roy; Vinall, Shan L.; Xue, Luzheng; Speight, Graham; Townsend, Elizabeth R.; Gazi, Lucien; Whelan, C.J.; Armer, Richard E.; Payton, Mark A.; Hunter, Michael G. (2012-02)D prostanoid receptor 2 (DP2) [also known as chemoattractant receptor-homologous molecule expressed on T helper 2 (Th2) cells (CRTH2)] is selectively expressed by Th2 lymphocytes, eosinophils, and basophils and mediates ...