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Browsing by Author "Potter, C.M.F."
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Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Kirkby, N.S.; Lundberg, M.H.; Harrington, L.S.; Leadbeater, P.D.M.; Potter, C.M.F.; Al-Yamani, M.; Adeyemi, O.; Mitchell, J.A.; Warner, T.D.; Milne, G.L. (2012-10-23)Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production ... -
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms
Potter, C.M.F.; Lundberg, M.H.; Harrington, L.S.; Moshkov, A.V.; Gorelik, J.; Mitchell, J.A.; Warboys, C.M.; Weinberg, P.D.; Warner, T.D.; Berson, R.E. (2011-02)Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2. Methods and ...