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Browsing by Author "Reid, Monica L."
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Determining degree of saturation after application of transiently supersaturated metered dose aerosols for topical delivery of corticosteroids
Jones, Stuart A.; Reid, Monica L.; Brown, Marc (2009-02)A transiently supersaturated drug delivery system has the potential to enhance topical drug delivery via heightened thermodynamic activity. The aim of this work was to quantify the degree of saturation (DS) for transiently ... -
An investigation into solvent-membrane interactions when assessing drug release from organic vehicles using regenerated cellulose membranes
Reid, Monica L.; Brown, Marc; Moss, Gary P.; Jones, Stuart A. (2008-09)The influence of organic solvents on artificial membranes when assessing drug release from topical formulations is, generally, poorly characterised yet current guidelines require no characterisation of the membrane before, ... -
Manipulation of corticosteroid release from a transiently supersaturated topical metered dose aerosol using a residual miscible co-solvent
Reid, Monica L.; Brown, Marc; Jones, Stuart A. (2008-11)Purpose. The creation of supersaturation transiently after application overcomes the issue of drug instability. However, if the solvents used to drive supersaturation evaporate too quickly, drug recrystallisation or rapid ... -
Transient drug supersaturation kinetics of beclomethasone dipropionate in rapidly drying films
Reid, Monica L.; Jones, Stuart A.; Brown, Marc (2009-04-17)Supersaturation is an effective method to enhance the delivery of active compounds into the skin, however the long-term instability of the drug in these formulations that exceed thermodynamic unity prevents clinical use. ...