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Browsing by Author "Rose, S."
Now showing items 1-9 of 9
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3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor
Iravani, Mahmoud M.; Haddon, C. O.; Rose, S.; Jenner, P. (2006-01-05)The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation ... -
Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
El Mohsen, M. M. A.; Iravani, Mahmoud M.; Spencer, J. P. E.; Rose, S.; Fahim, A. T.; Motawi, T. M. K.; Ismail, N. A. F.; Jenner, P. (2005-10-21)The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation ... -
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
Stockwell, K. A.; Scheller, D.; Rose, S.; Jackson, M. J.; Tayarani-Binazir, K.; Iravani, Mahmoud M.; Smith, L. A.; Olanow, C. W.; Jenner, P. (2009-10)Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ... -
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets
Stockwell, K. A.; Virley, D. J.; Perren, M.; Iravani, Mahmoud M.; Jackson, M. J.; Rose, S.; Jenner, P. (2008-05)L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation ... -
Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets
Stockwell, K. A.; Scheller, D. K. A.; Smith, L. A.; Rose, S.; Iravani, Mahmoud M.; Jackson, M. J.; Jenner, P. (2010-01)We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration Of L-DOPA in MPTP-treated marmosets. Now we investigate ... -
Continuous vs pulsatile administration of rotigotine in rat and monkey models of Parkinson's disease: A comparison
Scheller, D. K. A.; Schmidt, W. J.; Jackson, M. J.; Ruess, U.; Stockwell, K.; Heindl, M.; Iravani, Mahmoud M.; Tayarani-Binazir, K.; Rose, S.; Jenner, P. (2008) -
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration
Iravani, Mahmoud M.; Kashefi, K.; Mander, P.; Rose, S.; Jenner, P. (2002-03)The loss of dopaminergic neurotics in the substantia nigra with Parkinson's disease may result from inflammation-induced proliferation of microglia and reactive macrophages expressing inducible nitric oxide synthase (iNOS). ... -
MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome
Zeng, Bai-Yun; Iravani, Mahmoud M.; Lin, S. T.; Irifune, M.; Kuoppamaki, M.; Al-Barghouthy, G.; Smith, L.; Jackson, M. J.; Rose, S.; Medhurst, A.D.; Jenner, P. (2006-04)Dysfunction of the ubiquitin-proteasome system occurs in the substantia nigra (SN) in Parkinson's disease (PD). However, it is unknown whether this is a primary cause or a secondary consequence of other components of the ... -
Role of inducible nitric oxide synthase in N-methyl-D-aspartic acid-induced strio-nigral degeneration
Iravani, Mahmoud M.; Liu, L.; Rose, S.; Jenner, P. (2004-12-10)N-Methyl-D-aspartate (NMDA)-induced striatal excitotoxicity is mediated by nitric oxide (NO) but the role of inflammatory mechanisms and inducible nitric oxide synthase (iNOS) induction is not clear. Unilateral intrastriatal ...