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Browsing by Author "Small, J."
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Dexamethasone decreases plasma levels of the prochiral fenbendazole and its chiral and achiral metabolites in sheep
Sanchez, S.; Small, J.; Jones, D.G.; McKellar, Quintin (2003-07)1. The effect of co-administration of either short- or long-acting formulations of DXM on hepatic function and the plasma pharmacokinetic behaviour of prochiral fenbendazole (FBZ) and its metabolites was evaluated in sheep. ... -
Effects of formulation concentration on intravenous pharmacokinetics, chirality and in vitro solubility of oxfendazole and its metabolites in sheep
Sanchez, S.F.; Jones, D. G.; Small, J.; McKellar, Quintin (2005)This study compared pharmacokinetic (PK) profiles in sheep dosed intravenously with three different concentrations of oxfendazole (OFZ). An in vitro plasma OFZ solubility study provided additional information on plasma ... -
Plasma achiral and chiral pharmacokinetic behaviour of intravenous oxfendazole co-administered with piperonyl butoxide in sheep
Sanchez, S.; Jones, D.G.; Small, J.; McKellar, Quintin (2002-02)Co-administration of piperonyl butoxide (PB) potentiates fenbendazole (FBZ) in small ruminants. The resultant increase in bioavailability of FBZ and its metabolite oxfendazole (OFZ) has important implications for the ...