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Browsing by Author "Stephenson, Keith"
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Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production
Underwood, Sarah; Guan, Shuang; Vijayasubhash, Vinod; Baines, Simon D.; Graham, Luke; Lewis, Richard J.; Wilcox, M. H.; Stephenson, Keith (2009)Clostridium difficile is responsible for significant mortality and morbidity in the hospitalized elderly. C. difficile spores are infectious and are a major factor contributing to nosocomial transmission. The Spo0A response ... -
Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains
Fawley, Warren N; Underwood, Sarah; Freeman, Jane; Baines, Simon D.; Saxton, Katie; Stephenson, Keith; Owens, Robert C.; Wilcox, M. H. (2007)To compare the effects of hospital cleaning agents and germicides on the survival of epidemic Clostridium difficile strains. -
Structural analysis of divalent metals binding to the Bacillus subtilis response regulator Spo0F : the possibility for In vitro metalloregulation in the initiation of sporulation
Kojetin, D. J.; Thompson, R. J.; Benson, L. M.; Naylor, S.; Waterman, J.; Davies, Keith; Opperman, Charles H.; Stephenson, Keith; Hoch, J. A.; Cavanagh, J. (2005-10)The presence of a divalent metal ion in a negatively charged aspartic acid pocket is essential for phosphorylation of response regulator proteins. Here, we present metal binding studies of the Bacillus subtilis response ...