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Browsing by Author "Todd, Susan"
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Cross-sector surveys assessing perceptions of key stakeholders towards barriers, concerns and facilitators to the appropriate use of adaptive designs in confirmatory trials
Dimairo, Munyaradzi; Julious, Steven; Todd, Susan; Nicholl, Jonathan; Boote, Jonathan (2015-12-23)Background Appropriately conducted adaptive designs (ADs) offer many potential advantages over conventional trials. They make better use of accruing data, potentially saving time, trial participants, and limited resources ... -
Development of a Food-Exchange Model to Replace Saturated Fat with MUFAs and n-6 PUFAs in Adults at Moderate Cardiovascular Risk
Weech, Michelle; Vafeiadou, Katerina; Hasaj, Marinela; Todd, Susan; Yaqoob, Parveen; Jackson, Kim G.; Lovegrove, Julie A. (2014-06-01)The recommendation to reduce saturated fatty acid (SFA) consumption to ≤10% of total energy (%TE) is a key public health target aimed at lowering cardiovascular disease (CVD) risk. Replacement of SFA with unsaturated fats ... -
Missing steps in a staircase : a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials
Dimairo, Munya; Boote, Jonathan; Julious, Steven A.; Nicholl, Jon; Todd, Susan (2015-09-28)Despite the promising benefits of adaptive designs (ADs), their routine use, especially in confirmatory trials, is lagging behind the prominence given to them in the statistical literature. Much of the previous research ... -
A review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticles
Vafeiadou, Katerina; Weech, Michelle; Sharma, Vandana; Yaqoob, Parveen; Todd, Susan; Williams, Christine M.; Jackson, Kim G.; Lovegrove, Julie A. (2012-02)Vascular dysfunction is recognised as an integrative marker of CVD. While dietary strategies aimed at reducing CVD risk include reductions in the intake of SFA, there are currently no clear guidelines on what should replace ...