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Browsing by Author "Todhunter, Sharie L."
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Comparison of planktonic and biofilm-associated communities of Clostridium difficile and indigenous gut microbiota in a triple-stage chemostat gut model
Crowther, Grace S.; Chilton, Caroline H.; Todhunter, Sharie L.; Nicholson, Scott; Freeman, Jane; Baines, Simon D.; Wilcox, Mark H. (2014-04-30)BACKGROUND: Biofilms are characteristic of some chronic or recurrent infections and this mode of growth tends to reduce treatment efficacy. Clostridium difficile infection (CDI) is associated with a high rate of recurrent ... -
Development and validation of a chemostat gut model to study both planktonic and biofilm modes of growth of Clostridium difficile and human microbiota
Crowther, Grace S.; Chilton, Caroline H.; Todhunter, Sharie L.; Nicholson, Scott; Freeman, Jane; Baines, Simon D.; Wilcox, Mark H. (2014-02-06)The human gastrointestinal tract harbours a complex microbial community which exist in planktonic and sessile form. The degree to which composition and function of faecal and mucosal microbiota differ remains unclear. We ... -
Efficacy of novel antimicrobial agent SMT-19969 (SMT) against simulated Clostridium difficile infection in an in vitro human gut model
Baines, Simon D.; Freeman, J.; Huscroft, Grace S.; Todhunter, Sharie L.; Wilcox, M. H.; Vickers, R. (2011-09)Background: C. difficile infection (CDI) is the leading cause of nosocomial diarrhoea. Current CDI therapy is limited to metronidazole (M) or vancomycin. Recent evidence suggests reduced M efficacy and emergence of reduced ... -
Evaluation of antimicrobial activity of ceftaroline against Clostridium difficile and propensity to induce C. difficile infection in an in vitro human gut model
Baines, Simon D.; Chilton, Caroline H.; Crowther, Grace S.; Todhunter, Sharie L.; Freeman, Jane; Wilcox, Mark H. (2013)OBJECTIVES: To examine the effects of exposure to ceftaroline or ceftriaxone on the epidemic Clostridium difficile strain PCR ribotype 027 and the indigenous gut microflora in an in vitro human gut model. Additionally, the ... -
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
Baines, Simon D.; Noel, Alan R.; Huscroft, Grace S.; Todhunter, Sharie L.; O'Connor, Rachael; Hobbs, Joanne K.; Freeman, Jane; Lovering, Andy M.; Wilcox, M. H. (2011)Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI. -
Mixed infection by Clostridium difficile in an in vitro model of the human gut
Baines, Simon D.; Crowther, Grace S.; Todhunter, Sharie L.; Freeman, Jane; Chilton, Caroline H.; Fawley, Warren N.; Wilcox, Mark H. (2013)OBJECTIVES: Clostridium difficile infection (CDI) is still a major clinical challenge. Previous studies have demonstrated multiple distinct C. difficile strains in the faeces of patients with CDI; yet whether true mixed ... -
Nitazoxanide is active against Clostridium difficile strains with reduced susceptibility to metronidazole
Freeman, Jane; Baines, Simon D.; Todhunter, Sharie L.; Huscroft, Grace S.; Wilcox, M. H. (2011)Treatment strategies for Clostridium difficile infection (CDI) have changed little over the past two decades. Metronidazole and vancomycin continue to be the first-line antimicrobial treatments for CDI.1 While the drugs ...