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Browsing by Author "Traynor, Matthew"
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Predicting Skin Permeability by means of Computational Approaches : Reliability and Caveats in Pharmaceutical Studies
Pecoraro, Beatrice; Tutone, Marco; Hoffman, Ewelina; Hutter, Victoria; Almerico, Anna Maria; Traynor, Matthew (2019-05-28)The skin is the main barrier between the internal body environment and the external one. The characteristics of this barrier and its properties are able to modify and affect drug delivery and chemical toxicity parameters. ... -
A quantitative structure-permeability relationship model for split-thickness skin absorption, reasoning for the choice of the database.
Pecoraro, Beatrice; Hoffman, Ewelina; Hutter, Victoria; Traynor, Matthew (2018-06-20)The skin is the largest organ in the human body, protecting the body from xenobiotic invasion (1). Local and systemic drugs may also be administered through the skin, therefore the need to measure the permeability of the ... -
Sebomic identification of sex- and ethnicity-specific variations in residual skin surface components (RSSC) for bio-monitoring or forensic applications
Shetage, Satyajit; Traynor, Matthew; Brown, Marc; Chilcott, Robert (2018-08-21)Background: “Residual skin surface components” (RSSC) is the collective term used for the superficial layer of sebum, residue of sweat, small quantities of intercellular lipids and components of natural moisturising factor ...