Browsing by Author "Turner, Rob B."

Now showing items 1-3 of 3

    • Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro 

      Stewart, C.A.; Turner, Rob B.; Brown, Marc; Traynor, M.J. (Royal Society of Chemistry, 2014-04-14)
      Any chemical that is applied to the skin has the potential to induce a skin reaction. These reactions are complicated and are difficult to fully replicate in vitro and may exhibit species variations when reproduced in vivo. ...

    • Free radical facilitated damage of ungual keratin 

      Khengar, Rajeshree H.; Brown, Marc; Turner, Rob B.; Traynor, M.J.; Holt, Katherine B.; Jones, Stuart A. (2010-09-01)
      Thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) are thought to disrupt alpha-keratin disulfide links in the nail However, optimal clinical use of these agents to improve the treatment of nail disorders is ...

    • Overcoming the nail barrier : A systematic investigation of ungual chemical penetration enhancement 

      Brown, Marc; Khengar, Rajeshree H.; Turner, Rob B.; Forbes, B.; Traynor, M.J.; Evans, C.R.G.; Jones, S. A. (2009-03-31)
      This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration ...