Browsing by Author "Varki, Ajit"

Now showing items 1-5 of 5

    • Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis 

      Kawanishi, Kunio; Saha, Sudeshna; Diaz, Sandra; Vaill, Michael; Sasmal, Aniruddha; Siddiqui, Shoib S; Choudhury, Biswa P; Sharma, Kumar; Chen, Xi; Schoenhofen, Ian C; Sato, Chihiro; Kitajima, Ken; Freeze, Hudson H; Münster-Kühnel, Anja; Varki, Ajit (2021-03-01)
      Human metabolic incorporation of nonhuman sialic acid (Sia) N-glycolylneuraminic acid into endogenous glycans generates inflammation via preexisting antibodies, which likely contributes to red meat-induced atherosclerosis ...

    • Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells 

      Stanczak, Michal A; Siddiqui, Shoib S; Trefny, Marcel P; Thommen, Daniela S; Boligan, Kayluz Frias; von Gunten, Stephan; Tzankov, Alexandar; Tietze, Lothar; Lardinois, Didier; Heinzelmann-Schwarz, Viola; von Bergwelt-Baildon, Michael; Zhang, Wu; Lenz, Heinz-Josef; Han, Younghun; Amos, Christopher I; Syedbasha, Mohammedyaseen; Egli, Adrian; Stenner, Frank; Speiser, Daniel E; Varki, Ajit; Zippelius, Alfred; Läubli, Heinz (2018-11-01)
      First-generation immune checkpoint inhibitors, including anti-CTLA-4 and anti-programmed death 1 (anti-PD-1) antibodies, have led to major clinical progress, yet resistance frequently leads to treatment failure. Thus, new ...

    • Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis 

      Siddiqui, Shoib S; Dhar, Chirag; Sundaramurthy, Venkatasubramaniam; Sasmal, Aniruddha; Yu, Hai; Bandala-Sanchez, Esther; Li, Miaomiao; Zhang, Xiaoxiao; Chen, Xi; Harrison, Leonard C; Xu, Ding; Varki, Ajit (2021-03-09)
      Blood pH is tightly maintained between 7.35 and 7.45, and acidosis (pH <7.3) indicates poor prognosis in sepsis, wherein lactic acid from anoxic tissues overwhelms the buffering capacity of blood. Poor sepsis prognosis is ...

    • Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E 

      Siddiqui, Shoib; Schwarz, Flavio; Springer, Stevan; Khedri, Zahra; Yu, Hai; Deng, Lingquan; Verhagen, Andrea; Naito-Matsui, Yuko; Jiang, Weiping; Kim, Daniel; Zhou, Jie; Ding, Beibei; Chen, Xi; Varki, Nissi; Varki, Ajit (2017-01-20)
      CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has ...

    • Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E 

      Siddiqui, Shoib; Schwarz, Flavio; Springer, Stevan; Khedri, Zahra; Yu, Hai; Deng, Lingquan; Verhagen, Andrea; Naito-Matsui, Yuko; Jiang, Weiping; Kim, Daniel; Zhou, Jie; Ding, Beibei; Chen, Xi; Varki, Nissi; Varki, Ajit (2017-01-20)
      CD33-related Siglecs are a family of proteins widely expressed on innate immune cells. Binding of sialylated glycans or other ligands triggers signals that inhibit or activate inflammation. Immunomodulation by Siglecs has ...