Browsing by Author "Wojciak-Stothard, Beata"

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    • Disruption of methylarginine metabolism impairs vascular homeostasis 

      Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)
      Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ...

    • A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension 

      Mohamed, Nura A.; Ahmetaj-Shala, Blerina; Duluc, Lucie; Mackenzie, Louise S.; Kirkby, Nicholas S.; Reed, Daniel M.; Lickiss, Paul D.; Davies, Robert P.; Freeman, Gemma R.; Wojciak-Stothard, Beata; Chester, Adrian H.; El-Sherbiny, Ibrahim M.; Mitchell, Jane A.; Yacoub, Magdi H. (2016-04)
      Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and ...