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Browsing by Author "Yellon, Derek M."
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Co-ordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats
Sack, Michael N.; Harrington, Louise; Jonassen, Anna K.; Mjos, O.D.; Yellon, Derek M. (2000-02)Fuel substrate utilization is highly regulated during cardiac development and with the onset of cardiac hypertrophy. Glucose and lactate are the predominant fuel substrates utilized during cardiac development. Postnatally, ... -
Effect of remote ischaemic conditioning on platelet reactivity and endogenous fibrinolysis in ST-elevation myocardial infarction- a substudy of the CONDI-2/ERIC4 PPCI randomised controlled trial
Gorog, Diana; Farag, Mohamed; Spinthakis, Nikolaos; Yellon, Derek M.; Bøtker†, Hans E; Kharbanda, Rajesh; Hausenloy, Derek (2020-03-12)Background: Remote ischaemic conditioning (RIC) has been shown to reduce myocardial infarct size in animal models of myocardial infarction. Platelet thrombus formation is a critical determinant of outcome in ST-segment ... -
Effect of Remote Ischaemic Conditioning on the inflammatory cytokine cascade of COVID-19 (RIC in COVID-19): a Randomized Controlled Trial
Lukhna, Kishal; do Carmo, Helison R. P.; Castillo, Alejandro Rossell; Davidson, Sean M.; Geffen, Hayli; Giesz, Sara; Golforoush, Pelin; Gonçalez Bovi, Ticiane; Gorog, Diana; Salama, Alan; Imamdin, Aqeela; Kalkhoran, Siavash; Lecour, Sandrine; Perroud Jr., Mauricio W.; Ntsekhe, Mpiko; Sposito, Andrei C.; Yellon, Derek M. (2022-11-29)Purpose Patients hospitalized with COVID-19 may develop a hyperinflammatory, dysregulated cytokine “storm” that rapidly progresses to acute respiratory distress syndrome, multiple organ dysfunction, and even death. Remote ...