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Browsing by Author "Young, Adam"
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A 5 item version of the Compliance Questionnaire for Rheumatology (CQR5) successfully identifies low adherence to DMARDs
Hughes, Lyndsay D.; Done, D.J.; Young, Adam (2013-10)Taking DMARDs as prescribed is an essential part of self-management for patients with Rheumatoid Arthritis. To date, the Compliance Questionnaire for Rheumatology (CQR) is the only self-report adherence measure created ... -
Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery : Combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds
Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick; Gough, Andrew; Devlin, Joe; Emery, Paul; Waterhouse, Lynn; James, David; Tate, Helen; Boys, Cathy; Williams, Peter; White, Dora; Dart, Helen; Winfield, John; Seymour, Annie; Williams, Richard; Blunn, Karina; McDowell, Jackie; Prouse, Peter; Andrews, Sheryl; Wilson, Deborah; Magliano, Malgorzata; Perks, Ursula; Coulson, Amanda; Hassle, Andrew; Kirwan, Michele; Leone, Francesca; Dunne, Ciaran; Hawley, Lindsey; Creamer, Paul; Taylor, Julie; Wilmott, Wendy; Knights, Sally; Rowland-Axe, Rebecca; Green, Sandra; Simmons, Dawn; David, Joel; Cox, Maureen; Bukhari, Marwan; Evans, Bronwen; Batley, Michael; Oram, Catherine; ERAS and ERAN (2016-11-10)Objectives: To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods: Health Assessment Questionnaire (HAQ) disability scores ... -
The association between social deprivation and disease activity in rheumatoid arthritis: A systematic literature review
Dey, Mrinalini; Busby, Amanda; Ewell, Helen; Lempp, Heidi; Pratt, Arthur; Young, Adam; Isaacs, John; Nikiphorou, Elena (2022-04-21)Physical and mental illnesses are driven by ethnicity, social, environmental and economic determinants. Novel theoretical frameworks in rheumatoid arthritis (RA) focus on links and adverse interactions between and within ... -
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response
Viatte, Sebastien; Plant, Darren; Han, Buhm; Fu, Bo; Yarwood, Annie; Thomson, Wendy; Symmons, Deborah P.M.; Worthington, Jane; Young, Adam; Hyrich, Kimme L.; Morgan, Ann W.; Wilson, Anthony G.; Isaacs, John D.; Raychaudhuri, Soumya; Barton, Anne (2015-04-28)IMPORTANCE: Advances have been made in identifying genetic susceptibility loci for autoimmune diseases, but evidence is needed regarding their association with prognosis and treatment response. OBJECTIVE: To assess whether ... -
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis : experience in the ERAN inception cohort
McWilliams, Daniel F.; Kiely, Patrick D. W.; Young, Adam; Walsh, David A. (2013-05)Outcomes in early Rheumatoid Arthritis (RA) may be improved by rapidly establishing a stable and effective disease modifying anti-rheumatic drug (DMARD) treatment regimen. We aimed to investigate whether baseline factors ... -
Bloody diarrhoea : A rare presentation of a systemic disease
Mann, S.D.; Young, Adam; Barrison, Ian; Catnach, S. (2003)Bloody diarrhoea in adolescents is usually due to enteric infection or inflammatory bowel disease. We describe a patient with bloody diarrhoea and endoscopic features of colitis in association with a systemic vasculitis. ... -
Can Early, Clinically Significant Radiographic Progression In The First Year Of Disease Predict Orthopaedic Surgery In Patients With Rheumatoid Arthritis?
Carpenter, Lewis; Jayakumar, Keeranur; Nikiphorou, Elena; Norton, Sam; Dixey, Josh; Young, Adam (2014-04)BACKGROUND: Orthopaedic intervention is an important outcome in Rheumatoid Arthritis (RA). The use of radiographic data in the early stages of the disease and its importance in determining future RA related outcomes is ... -
Childhood dermatomyositis recurring in adulthood half a century later
Ismajli, M.; Nikiphorou, E.; Young, Adam (2013-09-02)A 62-year-old woman presented to the emergency department with malaise, lethargy and proximal muscle weakness. She had a similar presentation in childhood. A muscle biopsy was inconclusive, however, she was treated for a ... -
The clinical effectiveness and cost-effectiveness of treat-to-target strategies in rheumatoid arthritis : a systematic review and cost-effectiveness analysis
Wailoo, Allan; Hock, Emma S; Stevenson, Matt; Martyn-St James, Marrissa; Rawdin, Andrew; Simpson, Emma; Wong, Ruth; Dracup, Naila; Scott, David L; Young, Adam (National Institute for Health Research (NIHR), 2017-12-01)BACKGROUND: Treat to target (TTT) is a broad concept for treating patients with rheumatoid arthritis (RA). It involves setting a treatment target, usually remission or low disease activity (LDA). This is often combined ... -
Discordant inflammation and pain in early and established rheumatoid arthritis : Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data
McWilliams, Daniel F.; Ferguson, Eamonn; Young, Adam; Kiely, Patrick D.W.; Walsh, David A. (2016-12-13)Background: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ... -
Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae
McWilliams, Daniel F; Rahman, Shimin; James, Richard J E; Ferguson, Eamonn; Kiely, Patrick D W; Young, Adam; Walsh, David A (2019-11-18)Background: RA flares are common and disabling. They are described in terms of worsening inflammation but pain and inflammation are often discordant. To inform treatment decisions, we investigated whether inflammatory and ... -
Distinct psychological distress trajectories in rheumatoid arthritis : Findings from an inception cohort
Norton, Sam; Sacker, Amanda; Young, Adam; Done, D.J. (2011)Objective: As with other chronic physical illness, rates of depressive disorder are high in rheumatoid arthritis (RA). The aim of the current study was to identify distinct trajectories of psychological distress over 10 ... -
Do patients with rheumatoid arthritis want SMS text messages to remind them about hospital appointments and drug adherence?
Hughes, Lyndsay; Russell, Bridget; Jenkins, Suzanne; Done, D.J.; Young, Adam (2012-05-03) -
Hand and foot surgery rates in rheumatoid arthritis have declined from 1986 to 2011, but large-joint replacement rates remain unchanged : results from two UK inception cohorts
Nikiphorou, Elena; Carpenter, Lewis; Morris, Stephen; MacGregor, Alex J.; Dixey, Josh; Kiely, P.; Norton, S.; James, David W.; Walsh, D.; Young, Adam (2014-04-28)To assess whether there have been any secular changes in orthopedic interventions in patients with rheumatoid arthritis (RA) since 1986, as examined in 2 early rheumatoid arthritis (RA) inception cohorts with up to 25 years ... -
Have Radiographic Progression Rates in Early Rheumatoid Arthritis Changed? : A Systematic Review and Meta-analysis of Long-term Cohorts
Carpenter, Lewis; Nikiphorou, Elena; Sharpe, Rachel; Norton, Sam; Rennie, Kirsten; Bunn, Frances; Scott, David; Dixey, Josh; Young, Adam (2016-06-01)The objectives of this systematic review are to evaluate firstly, all published data on baseline and annual progression rates of radiographic damage from all longitudinal observational cohorts, and secondly, the association ... -
Health Assessment Questionnaire disability progression in early rheumatoid arthritis : systematic review and analysis of two inception cohorts
Norton, S.; Fu, B.; Scott, D.L.; Deighton, C.; Symmons, D.P.M.; Wailoo, A.J.; Tosh, J.; Lunt, M.; Davies, M.; Young, Adam; Verstappen, S. (2014-10)The Health Assessment Questionnaire is widely used in patients with inflammatory polyarthritis (IP) and its subset rheumatoid arthritis (RA). In this study we evaluated the progression of HAQ scores in RA by (i) systematically ... -
HLA-DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis
Ling, Stephanie F; Viatte, Sebastien; Lunt, Mark; Van Sijl, Alper M; Silva-Fernandez, Lucia; Symmons, Deborah P M; Young, Adam; Macgregor, Alexander J; Barton, Anne (2016-06-06)OBJECTIVE: Rheumatoid arthritis (RA) susceptibility HLA-DRB1 haplotypes based on amino acid positions 11/13, 71, and 74 predict radiographic damage. The mechanism of action is unknown, but it may be mediated by inflammation. ... -
Importance of registries in informing clinical practice for arthritis
Carpenter, Lewis; Nikiphorou, Elena; Young, Adam (2013-11)The gold standard in research for evidence that underlies clinical practice is the randomized controlled trial. In recent years it has been accepted that observational studies, which include disease and drug registries and ... -
Influence of Social Support, Financial Status, and Lifestyle on the Disparity Between Inflammation and Disability in Rheumatoid Arthritis
Gwinnutt, James M.; Norton, Sam; Hyrich, Kimme L.; Lunt, Mark; Combe, Bernard; Rincheval, Nathalie; Ruyssen‐Witrand, Adeline; Fautrel, Bruno; McWilliams, Daniel F.; Walsh, David A.; Nikiphorou, Elena; Kiely, Patrick D. W.; Young, Adam; Chipping, Jacqueline R.; MacGregor, Alex; Verstappen, Suzanne M. M. (2023-04-24)Objective: To investigate how social support, financial status, and lifestyle influence the development of excess disability in rheumatoid arthritis (RA). Methods: Data were obtained from the Étude et Suivi des Polyarthrites ... -
Large joints are progressively involved in rheumatoid arthritis irrespective of rheumatoid factor status—results from the early rheumatoid arthritis study
Zhao, Sizheng Steven; Nikiphorou, Elena; Young, Adam; Kiely, Patrick D. W. (2021-08-16)This study aimed to examine the progression of large joint involvement from early to established RA in terms of range of movement (ROM) and time to joint surgery, according to the presence of rheumatoid factor (RF). We ...