Browsing by Author "Zakkar, Mustafa"

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Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow

Ali, Faisal; Zakkar, Mustafa; Karu, Kersti; Lidington, Elaine A.; Hamdulay, Shahir S.; Boyle, Joseph J.; Zloh, Mire; Bauer, Andrea; Haskard, Dorian O; Evans, Paul C.; Mason, Justin C. (2009-07)

In addition to cholesterol-lowering properties, statins exhibit lipid-independent immunomodulatory, anti-inflammatory actions. However, high concentrations are typically required to induce these effects in vitro, raising ...