Browsing by Author "van de Bunt, Martijn"

Now showing items 1-2 of 2

    • Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells 

      Haythorne, Elizabeth; Rohm, Maria; van de Bunt, Martijn; Brereton, Melissa F; Tarasov, Andrei I; Blacker, Thomas S; Sachse, Gregor; Silva Dos Santos, Mariana; Terron Exposito, Raul; Davis, Simon; Baba, Otto; Fischer, Roman; Duchen, Michael R; Rorsman, Patrik; MacRae, James I; Ashcroft, Frances M (2019-06-06)
      Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose ...

    • Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells 

      Hastoy, Benoît; Godazgar, Mahdieh; Clark, Anne; Nylander, Vibe; Spiliotis, Ioannis; van de Bunt, Martijn; Chibalina, Margarita V; Barrett, Amy; Burrows, Carla; Tarasov, Andrei I; Scharfmann, Raphael; Gloyn, Anna L; Rorsman, Patrik (2018-11-19)
      Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their ...