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dc.contributor.authorPatel, Viralkumar
dc.contributor.authorLiu, Fang
dc.contributor.authorBrown, Marc
dc.identifier.citationPatel , V , Liu , F & Brown , M 2012 , ' Modelling the oral cavity : In vitro and in vivo evaluations of buccal drug delivery systems ' , Journal of Controlled Release , vol. 161 , no. 3 , pp. 746-756 .
dc.identifier.otherPURE: 914199
dc.identifier.otherPURE UUID: 6d71b583-2e82-4a47-af11-bb383af5e21d
dc.identifier.otherScopus: 84864604538
dc.description.abstractThe delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. However, the design of appropriate in vitro and in vivo methods to evaluate the behavior of these delivery systems is often ignored. This review aims to outline the progress in the in vitro and in vivo modeling of buccal drug delivery and provide a critical review of currently used methods. The development of a range of in vitro methods is outlined including disintegration/dissolution testing, in vitro mucoadhesion tests, in vitro residence time evaluation and permeability studies. The suitability of commonly used animal models for in vivo evaluation is also discussed and the physiological comparison of the animal oral cavity with that of a human's is described. --------------------------------------------------------------------------------en
dc.relation.ispartofJournal of Controlled Release
dc.subjectBuccal Mucosa
dc.subjectBuccal Drug Delivery System
dc.subjectIn vitro–in vivo correlation
dc.subjectEpithelial cell culture
dc.titleModelling the oral cavity : In vitro and in vivo evaluations of buccal drug delivery systemsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionModified Release Dosage Forms
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed

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