dc.contributor.author | Chandna, Shahid | |
dc.contributor.author | Da Silva Gane, Maria | |
dc.contributor.author | Marshall, Catherine | |
dc.contributor.author | Warwicker, Paul | |
dc.contributor.author | Greenwood, Roger | |
dc.contributor.author | Farrington, Ken | |
dc.date.accessioned | 2013-02-26T14:59:51Z | |
dc.date.available | 2013-02-26T14:59:51Z | |
dc.date.issued | 2011-05 | |
dc.identifier.citation | Chandna , S , Da Silva Gane , M , Marshall , C , Warwicker , P , Greenwood , R & Farrington , K 2011 , ' Survival of elderly patients with stage 5 CKD : comparison of conservative management and renal replacement therapy ' , Nephrology Dialysis Transplantation , vol. 26 , no. 5 , pp. 1608 -1614 . https://doi.org/10.1093/ndt/gfq630 | |
dc.identifier.issn | 0931-0509 | |
dc.identifier.other | PURE: 1441333 | |
dc.identifier.other | PURE UUID: 23fdbeb6-2a4d-47c7-b9da-f497ea7773ec | |
dc.identifier.other | Scopus: 79955611168 | |
dc.identifier.uri | http://hdl.handle.net/2299/10076 | |
dc.description | © The Author 2010. Published by Oxford University Press on behalf of the ERA-EDTA. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited | |
dc.description.abstract | Background. Elderly patients with end-stage renal disease and severe extra-renal comorbidity have a poor prognosison renal replacement therapy (RRT) and may opt to be managed conservatively (CM). Information on the survival of patients on this mode of therapy is limited. Methods. We studied survival in a large cohort of CM patients in comparison to patients who received RRT. Results. Over an 18-year period, we studied 844 patients, 689 (82%) of whom had been treated by RRT and 155 (18%) were CM. CM patients were older and a greater proportion had high comorbidity. Median survival from entry into stage 5 chronic kidney disease was less in CM than in RRT (21.2 vs 67.1 months: P < 0.001). However, in patients aged >75 years when corrected for age, high comorbidity and diabetes, the survival advantage from RRT was ~4 months, which was not statistically significant. Increasing age, the presence of high comorbidity and the presence of diabetes were independent determinants of poorer survival in RRT patients. In CM patients, however, age >75 years and female gender independently predicted better survival. Conclusions. In patients aged >75 years with high extrarenal comorbidity, the survival advantage conferred by RRT over CM is likely to be small. Age >75 years and female gender predicted better survival in CM patients. The reasons for this are unclear. | en |
dc.format.extent | 7 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nephrology Dialysis Transplantation | |
dc.subject | chronic kidney disease | |
dc.subject | comorbidity | |
dc.subject | conservative management | |
dc.subject | elderly | |
dc.subject | SURVIVAL | |
dc.title | Survival of elderly patients with stage 5 CKD : comparison of conservative management and renal replacement therapy | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | Centre for Postgraduate Medicine | |
dc.contributor.institution | Postgraduate Medicine | |
dc.contributor.institution | Health Services and Medicine | |
dc.contributor.institution | Pharmacology and Clinical Science Research | |
dc.description.status | Peer reviewed | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | https://doi.org/10.1093/ndt/gfq630 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |