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dc.contributor.authorHan, Yang-guang
dc.contributor.authorXu, Jing
dc.contributor.authorLi, Zhi-gui
dc.contributor.authorRen, Guogang
dc.contributor.authorYang, Zhuo
dc.date.accessioned2013-03-14T10:59:49Z
dc.date.available2013-03-14T10:59:49Z
dc.date.issued2012-10
dc.identifier.citationHan , Y , Xu , J , Li , Z , Ren , G & Yang , Z 2012 , ' In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells ' , NeuroToxicology , vol. 33 , no. 5 , pp. 1128-1134 . https://doi.org/10.1016/j.neuro.2012.06.004
dc.identifier.issn0161-813X
dc.identifier.otherPURE: 914276
dc.identifier.otherPURE UUID: fa340995-3c76-4f08-ba48-65a729aa244a
dc.identifier.otherScopus: 84867232136
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373260
dc.identifier.urihttp://hdl.handle.net/2299/10144
dc.description.abstractThe present study aimed to evaluate the potential toxicity and the general mechanism involved in multi-walled carbon nanotubes (MWCNT)-induced cytotoxicity in C6 rat glioma cell line. Two kinds of MWCNT, which were coded as MWCNT1 (measured 10–20 nm in diameter and 2 ␣m in average length) and MWCNT2 (measured 40–100 nm in diameter and 10 ␣m in average length), were used in this study. To elucidate the possible mechanisms of cytotoxicity induced by MWCNT, MTT assay and flow cytometry analysis for apoptosis and cell cycle, MDA and SOD assays for oxidative stress were quantitatively assessed. The exposure of C6 rat glioma cells to different sizes of two kinds of carbon nanotubes at concentrations between 25 and 400 ␣g/ml decreased the cell viability in a concentration- and time- dependent manner. The exposure of C6 rat glioma cells to MWCNT (200–400 ␣g/ml) resulted in a concentration dependent cell apoptosis and G1 cell cycle arrest, and increased the level of oxidative stress. Results demonstrate that smaller size of MWCNT seems to be more toxic than that of larger one. MWCNT-induced cytotoxicity in C6 cells is probably due to the increased oxidative stress.en
dc.language.isoeng
dc.relation.ispartofNeuroToxicology
dc.subjectnano carbon tubes
dc.subjectApoptosis
dc.subjectoxidative stress
dc.subjectC6 rat glioma cells
dc.subjectin vitro
dc.titleIn vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cellsen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Engineering and Technology
dcterms.dateAccepted2012-10
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.neuro.2012.06.004
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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