| dc.contributor.author | Baines, Simon D. | |
| dc.contributor.author | Freeman, Jane | |
| dc.contributor.author | Wilcox, M. H. | |
| dc.date.accessioned | 2013-03-20T14:59:51Z | |
| dc.date.available | 2013-03-20T14:59:51Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Baines , S D , Freeman , J & Wilcox , M H 2009 , ' Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection ' , Antimicrobial Agents and Chemotherapy , vol. 53 , no. 5 , pp. 2202-4 . https://doi.org/10.1128/AAC.01085-08 | |
| dc.identifier.issn | 1098-6596 | |
| dc.identifier.uri | http://hdl.handle.net/2299/10228 | |
| dc.description.abstract | The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials. | en |
| dc.format.extent | 3 | |
| dc.format.extent | 217391 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Antimicrobial Agents and Chemotherapy | |
| dc.title | Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection | en |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.contributor.institution | Microbiology and Biotechnology | |
| dc.contributor.institution | Biosciences Research Group | |
| dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
| dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
| dc.contributor.institution | Centre for Future Societies Research | |
| dc.description.status | Peer reviewed | |
| dc.identifier.url | http://www.scopus.com/inward/record.url?scp=66149098843&partnerID=8YFLogxK | |
| rioxxterms.versionofrecord | 10.1128/AAC.01085-08 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
