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dc.contributor.authorBaines, Simon D.
dc.contributor.authorFreeman, Jane
dc.contributor.authorWilcox, M. H.
dc.date.accessioned2013-03-20T14:59:51Z
dc.date.available2013-03-20T14:59:51Z
dc.date.issued2009
dc.identifier.citationBaines , S D , Freeman , J & Wilcox , M H 2009 , ' Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection ' , Antimicrobial Agents and Chemotherapy , vol. 53 , no. 5 , pp. 2202-4 . https://doi.org/10.1128/AAC.01085-08
dc.identifier.issn1098-6596
dc.identifier.otherPURE: 1351824
dc.identifier.otherPURE UUID: 02804db6-3231-49b7-b6ef-5ccd381758fb
dc.identifier.otherPubMed: 19223641
dc.identifier.otherScopus: 66149098843
dc.identifier.urihttp://hdl.handle.net/2299/10228
dc.description.abstractThe efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.en
dc.format.extent3
dc.language.isoeng
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.titleTolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infectionen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionMicrobiology and Biotechnology
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=66149098843&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1128/AAC.01085-08
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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