Show simple item record

dc.contributor.authorMcKellar, Quintin
dc.contributor.authorPearson, T.
dc.contributor.authorBogan, J.A.
dc.contributor.authorGaibraith, E.A.
dc.contributor.authorLees, P.
dc.contributor.authorLudwig, B.
dc.contributor.authorTiberghien, M.P.
dc.date.accessioned2013-03-20T15:29:57Z
dc.date.available2013-03-20T15:29:57Z
dc.date.issued1990
dc.identifier.citationMcKellar , Q , Pearson , T , Bogan , J A , Gaibraith , E A , Lees , P , Ludwig , B & Tiberghien , M P 1990 , ' Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog ' , Journal of Small Animal Practice , vol. 31 , no. 9 , pp. 443-448 . https://doi.org/10.1111/j.1748-5827.1990.tb00510.x
dc.identifier.issn1748-5827
dc.identifier.otherPURE: 1445584
dc.identifier.otherPURE UUID: ea3e6a4a-36c1-404d-8c5e-a635b62594dd
dc.identifier.otherBibtex: urn:bdd20cc8ba3cefa9ac95802cd1381cb3
dc.identifier.otherScopus: 84985357036
dc.identifier.urihttp://hdl.handle.net/2299/10235
dc.description.abstractThe non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an oral tablet formulation at a dose rate of 0–7 mg/kg and 4-0 mg/kg orally for pharmacokinetic studies. It was also administered as an oral tablet formulation at a dose rate of 9-0 mg/kg orally daily for 14 days in a tolerance study. The pharmacokinetics following intravenous administration at a dose rate of 0–7 mg/kg indicate that carprofen has a small volume of distribution (Vd area = 0–09-0-25 litres), a slow systemic clearance (Cls = 1–34-5-57 ml/min) and an elimination half-life of 3–20-11-77 hours. Both oral paste and tablet preparations were highly bioavailable and absorption was proportional to dose rate at 0–7 mg/kg and 4-0 mg/kg bodyweight. Given once daily at dose rates likely to be used clinically it is unlikely to accumulate in the plasma. Carprofen administered as a palatable paste at a dose rate of 0–7 mg/kg did not inhibit serum thromboxane generation and this drug may therefore have a mode of action different from most NSAIDs. Carprofen was well tolerated when administered as an oral tablet formulation at a dose rate of 9.0 mg/kg daily for 14 days in healthy beagle dogen
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofJournal of Small Animal Practice
dc.titlePharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dogen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1748-5827.1990.tb00510.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record