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dc.contributor.authorRankin, Sarah
dc.contributor.authorReszka, Anthony P.
dc.contributor.authorHuppert, Julian
dc.contributor.authorZloh, Mire
dc.contributor.authorParkinson, Gary N.
dc.contributor.authorTodd, Alan K.
dc.contributor.authorLadame, Sylvain
dc.contributor.authorBalasubramanian, Shankar
dc.contributor.authorNeidle, Stephen
dc.identifier.citationRankin , S , Reszka , A P , Huppert , J , Zloh , M , Parkinson , G N , Todd , A K , Ladame , S , Balasubramanian , S & Neidle , S 2005 , ' Putative DNA quadruplex formation within the human c-kit oncogene ' , Journal of the American Chemical Society , vol. 127 , no. 30 , pp. 10584-9 .
dc.identifier.otherPURE: 1458290
dc.identifier.otherPURE UUID: 1d7e25fa-c8ad-438a-abe6-6f587bcae557
dc.identifier.otherPubMed: 16045346
dc.identifier.otherScopus: 23044485047
dc.description.abstractThe DNA sequence, d(AGGGAGGGCGCTGGGAGGAGGG), occurs within the promoter region of the c-kit oncogene. We show here, using a combination of NMR, circular dichroism, and melting temperature measurements, that this sequence forms a four-stranded quadruplex structure under physiological conditions. Variations in the sequences that intervene between the guanine tracts have been examined, and surprisingly, none of these modified sequences forms a quadruplex arrangement under these conditions. This suggests that the occurrence of quadruplex-forming sequences within the human and other genomes is less than was hitherto expected. The c-kit quadruplex may be a new target for therapeutic intervention in cancers where there is elevated expression of the c-kit gene.en
dc.relation.ispartofJournal of the American Chemical Society
dc.titlePutative DNA quadruplex formation within the human c-kit oncogeneen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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