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dc.contributor.authorLiao, Y. H.
dc.contributor.authorJones, Stuart A.
dc.contributor.authorForbes, B.
dc.contributor.authorMartin, Gary P.
dc.contributor.authorBrown, Marc
dc.date.accessioned2013-04-11T12:59:35Z
dc.date.available2013-04-11T12:59:35Z
dc.date.issued2005
dc.identifier.citationLiao , Y H , Jones , S A , Forbes , B , Martin , G P & Brown , M 2005 , ' Hyaluronan: Pharmaceutical characterization and drug delivery ' , Journal of Drug Delivery Science and Technology , vol. 12 , no. 6 , pp. 327-342 . https://doi.org/10.1080/10717540590952555
dc.identifier.issn1071-7544
dc.identifier.otherPURE: 628073
dc.identifier.otherPURE UUID: 529abb6e-bb3f-466b-bd86-e68d7b518c89
dc.identifier.otherWOS: 000232882700001
dc.identifier.otherScopus: 27644576663
dc.identifier.urihttp://hdl.handle.net/2299/10360
dc.description.abstractHyaluronic acid ( HA), is a polyanionic polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is most frequently referred to as hyaluronan because it exists in vivo as a polyanion and not in the protonated acid form. HA is distributed widely in vertebrates and presents as a component of the cell coat of many strains of bacteria. Initially the main functions of HA were believed to be mechanical as it has a protective, structure stabilizing and shock-absorbing role in the body. However, more recently the role of HA in the mediation of physiological functions via interaction with binding proteins and cell surface receptors including morphogenesis, regeneration, wound healing, and tumor invasion, as well as in the dynamic regulation of such interactions on cell signaling and behavior has been documented. The unique viscoelastic nature of hyaluronan along with its biocompatibility and nonimmunogenicity has led to its use in a number of cosmetic, medical, and pharmaceutical applications. More recently, HA has been investigated as a drug delivery agent for ophthalmic, nasal, pulmonary, parenteral, and dermal routes. The purpose of our review is to describe the physical, chemical, and biological properties of native HA together with how it can be produced and assayed along with a detailed analysis of its medical and pharmaceutical applications.en
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.subjectanalysis
dc.subjectdrug delivery
dc.subjecthyaluronan
dc.subjectphysiochemical properties
dc.subjecttopical
dc.subjectPERFORMANCE LIQUID-CHROMATOGRAPHY
dc.subjectINTRAARTICULAR SODIUM HYALURONATE
dc.subjectSIZE-EXCLUSION CHROMATOGRAPHY
dc.subjectGEL-PERMEATION CHROMATOGRAPHY
dc.subjectACID CARBAZOLE REACTION
dc.subjectIN-VITRO FERTILIZATION
dc.subjectHIGH-MOLECULAR-WEIGHT
dc.subjectLIGHT-SCATTERING
dc.subjectAQUEOUS-SOLUTION
dc.subjectOPHTHALMIC VEHICLES
dc.titleHyaluronan: Pharmaceutical characterization and drug deliveryen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2005
rioxxterms.versionofrecordhttps://doi.org/10.1080/10717540590952555
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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