Serum thromboxane generation by platelets in several domestic animal species

Abstract

Blood collected from calves, sheep, goats, pigs, dogs, horses, ponies and donkeys, was allowed to clot under standard conditions. Thromboxane B2 generated during the clotting process was measured by radioimmunoassay in serum harvested from each sample. Highly significant differences were found between species and also between genera within a species. Highest concentrations of thromboxane B2 were detected in the dog samples (887.7 +/- 123.7 ng/ml) and lowest concentrations in samples from sheep (2.7 +/- 0.2 ng/ml). The amount of thromboxane produced per unit number of circulating platelets or per unit volume of platelets in each species was not the same and it would appear that platelets from each species have different inherent ability to produce thromboxane under the stimulus applied, or that some species generate thromboxane from other sources during the clotting process.