| dc.contributor.author | Verbić, T.Z. | |
| dc.contributor.author | Juranić, I.O. | |
| dc.contributor.author | Drakulić, B.J. | |
| dc.contributor.author | Zloh, Mire | |
| dc.date.accessioned | 2013-04-25T10:20:01Z | |
| dc.date.available | 2013-04-25T10:20:01Z | |
| dc.date.issued | 2009-12-01 | |
| dc.identifier.citation | Verbić , T Z , Juranić , I O , Drakulić , B J & Zloh , M 2009 , ' The effect of phenyl substituents on C NMR shifts and metal ions binding to 4-Phenyl-2,4-dioxobutanoic acid derivatives ' , Letters in Organic Chemistry , vol. 5 , no. 8 , pp. 692-699 . https://doi.org/10.2174/157017808786857589 | |
| dc.identifier.issn | 1570-1786 | |
| dc.identifier.uri | http://hdl.handle.net/2299/10571 | |
| dc.description.abstract | Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alky1 substituted compounds, was observed. This observation might have pharmacological implications | en |
| dc.format.extent | 8 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Letters in Organic Chemistry | |
| dc.title | The effect of phenyl substituents on C NMR shifts and metal ions binding to 4-Phenyl-2,4-dioxobutanoic acid derivatives | en |
| dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
| dc.contributor.institution | Centre for Health Services and Clinical Research | |
| dc.description.status | Peer reviewed | |
| dc.identifier.url | http://www.scopus.com/inward/record.url?scp=70349624346&partnerID=8YFLogxK | |
| rioxxterms.versionofrecord | 10.2174/157017808786857589 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
