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dc.contributor.authorVerbic, Tatjana Z.
dc.contributor.authorDrakulic, Branko J.
dc.contributor.authorZloh, Mire
dc.contributor.authorJuranic, Ivan O.
dc.date.accessioned2013-04-30T07:25:03Z
dc.date.available2013-04-30T07:25:03Z
dc.date.issued2008-12
dc.identifier.citationVerbic , T Z , Drakulic , B J , Zloh , M & Juranic , I O 2008 , ' The Effect of Phenyl Substituents on C-13 NMR Shifts and Metal Ions Binding to 4-Phenyl-2,4-Dioxobutanoic Acid Derivatives ' , Letters in Organic Chemistry , vol. 5 , no. 8 , pp. 692-699 .
dc.identifier.issn1570-1786
dc.identifier.otherPURE: 1668985
dc.identifier.otherPURE UUID: 2d7bb092-1be0-4305-8c9f-03a39037c22e
dc.identifier.otherWOS: 000261926400017
dc.identifier.urihttp://hdl.handle.net/2299/10599
dc.description.abstractButanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alkyl substituted compounds, was observed. This observation might have pharmacological implications.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofLetters in Organic Chemistry
dc.subjectDESIGN
dc.subjectmetal complexation ability
dc.subjectUV/VIS spectroscopy
dc.subjectPHARMACOPHORE
dc.subjectDISCOVERY
dc.subjectMS
dc.subjectKETO-ENOL TAUTOMERIZATION
dc.subjectUPDATE
dc.subject4-Aryl-2,4-dioxobutanoic acids
dc.subjectBETA-DIKETONES
dc.subjectMODEL
dc.subjectLinear free energy relationships
dc.subjectNMR
dc.subjectHIV-1 INTEGRASE INHIBITORS
dc.subjectCHARACTER
dc.titleThe Effect of Phenyl Substituents on C-13 NMR Shifts and Metal Ions Binding to 4-Phenyl-2,4-Dioxobutanoic Acid Derivativesen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2008-12
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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