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dc.contributor.authorBoggio, J.C.
dc.contributor.authorValtorta, S.E.
dc.contributor.authorSanchez, S.
dc.contributor.authorMcKellar, Quintin
dc.identifier.citationBoggio , J C , Valtorta , S E , Sanchez , S & McKellar , Q 2001 , ' Chronobiological variations of indomethacin pharmacokinetic parameters in sheep ' , Journal of Veterinary Pharmacology and Therapeutics , vol. 24 , no. 4 , pp. 261-265 .
dc.identifier.otherPURE: 1416302
dc.identifier.otherPURE UUID: 7c49a186-4651-4c3e-b874-1ca8a4dccfc4
dc.identifier.otherBibtex: urn:ecac7cc91a8b2780a7c15a93658121da
dc.identifier.otherScopus: 0034887593
dc.description.abstractA two-phase study to investigate the influence of administration time on pharmacokinetics of indomethacin in sheep was performed. In phase I, 12 animals were allocated to four groups, each corresponding to a different time: 08:00, 14:00, 20:00, 02:00 h. Sheep received an intravenous administration of 1 mg/kg indomethacin. In phase II, each group was administered indomethacin with a 12-h difference compared to Phase I. The trial was performed in autumn, and animals were subjected to a natural light:dark cycle of 10:14 h. Blood samples were taken and processed by high performance liquid chromatography (HPLC) with ultraviolet detection. For each pharmacokinetic parameter, an analysis of variance was performed to outline the existence of chronobiological variations. Concentration at zero time (C-0), hybrid constant for distribution and its half life, hybrid constant for elimination and its half-life, volume of distribution ( V-d), area under the curve (AUC(infinity)) and clearance rate (CI), presented chronobiological variations (P < 0.05) and were fitted to a cosine equation. The following parameters adjusted to circadian rhythms: C-0 (acrophase: 13.9788 h); AUC(infinity) (acrophase: 13.4377 h); V-d (acrophase: 0.8245 h) and Cl (acrophase: 1.4965 h), It was concluded that pharmacokinetic parameters of intravenously injected indomethacin in sheep would behave in a different, though predictable, manner according to the animal's biological clock.en
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.titleChronobiological variations of indomethacin pharmacokinetic parameters in sheepen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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