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dc.contributor.authorThomas, S. R.
dc.contributor.authorGerhard, Ute
dc.identifier.citationThomas , S R & Gerhard , U 2004 , ' Open-access high-resolution mass spectrometry in early drug discovery ' , Journal of Mass Spectrometry , vol. 39 , no. 8 , pp. 942-948 .
dc.identifier.otherPURE: 848741
dc.identifier.otherPURE UUID: 8fcb3f7c-7753-4f17-8f90-a5d9d952e709
dc.identifier.otherWOS: 000223354900010
dc.identifier.otherScopus: 4444384472
dc.description.abstractTechniques such as mass spectrometry and NMR spectroscopy form an essential part of the medicinal chemist's toolbox for characterizing and assessing the purity of new molecules. Empowering medicinal chemists to gain early insight into their reaction products has a direct impact on productivity. Devolution of cutting-edge techniques from the specialist to the bench chemist also frees the specialist to concentrate on solving the more demanding of analytical problems. For open-access techniques to be taken up, they must be robust and be able to handle differing sample concentrations and varying sample complexities. This paper details the implementation of high-resolution liquid chromatography/mass spectrometry in open access to aid the medicinal chemist in characterizing desired products and identifying unexpected rearrangements, by-products and complete unknowns. Copyright (C) 2004 John Wiley Sons, Ltd.en
dc.relation.ispartofJournal of Mass Spectrometry
dc.titleOpen-access high-resolution mass spectrometry in early drug discoveryen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionMedicinal and Analytical Chemistry
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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