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dc.contributor.authorLadenheim, D.
dc.contributor.authorMartin, Gary P.
dc.contributor.authorMarriott, C.
dc.contributor.authorHollingsbee, D. A.
dc.contributor.authorBrown, Marc
dc.identifier.citationLadenheim , D , Martin , G P , Marriott , C , Hollingsbee , D A & Brown , M 1996 , ' An in-vitro study of the effect of hydrocolloid patch occlusion on the penetration of triamcinolone acetonide through skin in man ' , Journal of Pharmacy and Pharmacology , vol. 48 , no. 8 , pp. 806-811 .
dc.identifier.otherPURE: 631418
dc.identifier.otherPURE UUID: 57295c13-3463-41d4-9eeb-153db143884e
dc.identifier.otherWOS: A1996VK20600007
dc.identifier.otherScopus: 0029810058
dc.description.abstractThe aim of this study was to evaluate the effect of occlusion using hydrocolloid-containing patches on in-vitro triamcinolone acetonide (TACA) penetration of the epidermis while monitoring the uptake of water by the patches as a result of transepidermal water loss. The hydrocolloid patches were a laminate of a pressure-sensitive hydrophobic adhesive (containing a dispersion of 39% of either pectin or carmellose sodium) and a polyethylene film. The diffusion of a representative corticosteroid (TACA) through isolated epidermal sheet was shown to depend on the site from which the skin was removed. The two patch-types exhibited markedly different hydration rates when applied to the membranes. For example, after 96 h the carmellose sodium patch showed ten times the weight increase of the pectin patch. Epidermal diffusion rates were, however, similar, both showing a 3-4-fold enhancement over unoccluded conditions. The increase in TACA diffusion with the patches can be explained by the increase in skin hydration that occurs during occlusion. Despite the large differences in transepidermal water transfer through the epidermal membranes with the two types of hydrocolloid patch, however, this level of stratum corneum hydration was apparently similar. As the rate of diffusion was also independent of hydrocolloid patch component, it seems possible that the hydrophobic component of the patch matrix may also influence the level of skin hydration and consequent drug diffusion.en
dc.relation.ispartofJournal of Pharmacy and Pharmacology
dc.titleAn in-vitro study of the effect of hydrocolloid patch occlusion on the penetration of triamcinolone acetonide through skin in manen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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