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dc.contributor.authorMuscat, R.
dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorKruk, Z. L.
dc.date.accessioned2013-06-17T14:15:44Z
dc.date.available2013-06-17T14:15:44Z
dc.date.issued1996-12
dc.identifier.citationMuscat , R , Iravani , M M & Kruk , Z L 1996 , ' The role of ventral tegmental dopamine neurons in locomotor sensitization following quinpirole or (+)-amphetamine : Ex vivo voltammetric evidence ' Neuroscience , vol. 75 , no. 4 , pp. 1175-1184 . https://doi.org/10.1016/0306-4522(96)00389-2
dc.identifier.issn0306-4522
dc.identifier.otherPURE: 736158
dc.identifier.otherPURE UUID: 53cffb8b-218a-4ba5-9bfe-1014d34a89a4
dc.identifier.otherWOS: A1996VV14300018
dc.identifier.otherScopus: 0030298281
dc.identifier.urihttp://hdl.handle.net/2299/10798
dc.description.abstractBehavioural sensitization to the locomotor stimulating effects of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Following expression of sensitization, locomotor activity scores on day 9 were: vehicle 87 +/- 9, (+)-amphetamine 1441 +/- 227 and quinpirole 2078 +/- 214. Electrically stimulated dopamine release was measured on day 12 in ventral tegmental slices using fast cyclic voltammetry. Dopamine release was significantly elevated in the (+)-amphetamine- and quinpirole-treated groups when compared to vehicle-treated controls over a wide range of stimulation frequencies (5-200 Hz) and pulses (1-200). Quinpirole (1 mu M) in the perfusion fluid attenuated dopamine release following 40-pulse, 200-Hz electrical stimulation, by 31.6 +/- 2.8% in the ventral tegmental area of the vehicle-treated group, by 14.8 +/- 5.6% in the (+)-amphetamine-treated group and 8 +/- 7.3% in the quinpirole-treated group. This study shows that dopamine release is increased in the ventral tegmental area following sensitization with either a direct or indirectly acting dopamine agonist. The findings that dopamine release was elevated at all stimulation frequencies in sensitized animals, and that quinpirole only attenuated this release at the highest stimulation frequency, would suggest that in addition to D-2 autoreceptor subsensitivity, other mechanisms contribute to the enhanced release of dopamine in these animals.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofNeuroscience
dc.subjectbehavioural sensitization
dc.subjectventral tegmental area
dc.subject(+)-amphetamine
dc.subjectquinpirole
dc.subjectfast cyclic voltammetry
dc.subjectdopamine release
dc.subjectBEHAVIORAL SENSITIZATION
dc.subjectNUCLEUS-ACCUMBENS
dc.subjectEXTRACELLULAR DOPAMINE
dc.subjectINVIVO MICRODIALYSIS
dc.subjectSUBSTANTIA-NIGRA
dc.subjectAREA SENSITIZES
dc.subjectD1 RECEPTORS
dc.subjectAMPHETAMINE
dc.subjectCOCAINE
dc.subjectRAT
dc.titleThe role of ventral tegmental dopamine neurons in locomotor sensitization following quinpirole or (+)-amphetamine : Ex vivo voltammetric evidenceen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/0306-4522(96)00389-2
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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