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dc.contributor.authorRice, P.
dc.contributor.authorBrown, Roger F. R.
dc.contributor.authorLam, D. G. K.
dc.contributor.authorChilcott, Robert
dc.contributor.authorBennett, N. J.
dc.date.accessioned2013-06-20T08:30:47Z
dc.date.available2013-06-20T08:30:47Z
dc.date.issued2000-02
dc.identifier.citationRice , P , Brown , R F R , Lam , D G K , Chilcott , R & Bennett , N J 2000 , ' Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries ' , Burns , vol. 26 , no. 1 , pp. 34-40 .
dc.identifier.issn0305-4179
dc.identifier.otherPURE: 678722
dc.identifier.otherPURE UUID: 7227a40c-6115-44ed-a7a8-8018366db2e2
dc.identifier.otherWOS: 000084400800006
dc.identifier.otherScopus: 0033990191
dc.identifier.urihttp://hdl.handle.net/2299/10883
dc.description.abstractSince its first use on the battlefields of Northern France during the First World War (1914-1918), sulphur mustard has remained a significant chemical threat to military forces around the world. Progress towards an effective treatment for these injuries has been slow due to the lack of suitable animal models upon which to study the toxicology and pathology. However, porcine and human skin are similar in structure and exposures to sulphur mustard vapour have been performed on porcine models to define the development and subsequent resolution of mustard-induced skin injuries. Yucatan miniature (n = 12) and large white (n = 6) pig models were used to assess the usefulness of mechanical dermabrasion in accelerating the naturally slow rate of healing of sulphur mustard vapour-induced injuries to the skin. Burn injuries underwent debridement at 4 days postexposure and the resulting lesions were assessed at various time points up to 8 weeks post-abrasion. Rates of re-epithelialisation were accelerated in the dermabrasion (treated) vs the control (untreated) group by up to a factor of three (ANOVA: p = 0.0196, Yucatan; p = 0.165, large white pig). It was concluded that dermabrasion of sulphur mustard burns is a valuable procedure in the surgical management of these injuries. (C) 2000 Elsevier Science Ltd and ISBI. All rights reserved.en
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofBurns
dc.subjectsulphur mustard
dc.subjectskin burn(s)
dc.subjecthealing
dc.subjectsurgical treatment
dc.subjectdermabrasion
dc.subjectATHYMIC NUDE-MICE
dc.subjectSULFUR MUSTARD
dc.subjectSKIN
dc.subjectMINIPIG
dc.subjectMODEL
dc.subjectPIG
dc.titleDermabrasion - a novel concept in the surgical management of sulphur mustard injuriesen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionPharmaceutics
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionToxicology
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2000-02
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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