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dc.contributor.authorYff, B. T. S.
dc.contributor.authorRoyall, P.G.
dc.contributor.authorBrown, Marc
dc.contributor.authorMartin, Gary P.
dc.date.accessioned2013-06-24T14:55:06Z
dc.date.available2013-06-24T14:55:06Z
dc.date.issued2004-01-28
dc.identifier.citationYff , B T S , Royall , P G , Brown , M & Martin , G P 2004 , ' An investigation of calibration methods for solution calorimetry ' , International Journal of Pharmaceutics , vol. 269 , no. 2 , pp. 361-372 . https://doi.org/10.1016/j.ijpharm.2003.09.011
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 628748
dc.identifier.otherPURE UUID: 7ca7213c-d9a1-482d-abd2-ecc5be0ab544
dc.identifier.otherWOS: 000188608900008
dc.identifier.otherScopus: 0347990435
dc.identifier.urihttp://hdl.handle.net/2299/10922
dc.description.abstractSolution calorimetry has been used in a number of varying applications within pharmaceutical research as a technique for the physical characterisation of pharmaceutical materials, such as quantifying small degrees of amorphous content, identifying polymorphs and investigating interactions between drugs and carbohydrates or proteins and carbohydrates. A calibration test procedure is necessary to validate the instrumentation; a few of the suggested calibration reactions are the enthalpies of solution associated with dissolving Tris in 0.1 M HCl or NaCl, KCl or propan-1-ol in water. In addition, there are a number of different methods available to determine enthalpies of solution from the experimental data provided by the calorimeter, for example, the Regnault-Pfaundler's method, a graphical extrapolation based on the Dickinson method, or a manual integration-based method. Thus, the aim of the study was to investigate how each of these methods influences the values for the enthalpy of solution. Experiments were performed according to the method outlined by Hogan and Buckton [Int. J. Pharm. 207 (2000) 57] using KCl (samples of 50, 100 and 200 mg), Tris and sucrose as calibrants. For all three materials the manual integration method was found to be the most consistent with the KCl in water (sample mass of 200 mg) being the most precise. Thus, this method is recommended for the validation of solution calorimeters. (C) 2003 Elsevier B.V. All rights reserved.en
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.subjectsolution calorimetry
dc.subjectcalibrations
dc.subjectpotassium chloride
dc.subjectsucrose
dc.subjectSTANDARDS
dc.subjectWATER
dc.subjectSTATE
dc.titleAn investigation of calibration methods for solution calorimetryen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2003.09.011
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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