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dc.contributor.authorStear, M.J.
dc.contributor.authorBairden, K.
dc.contributor.authorBishop, S.C.
dc.contributor.authorBuitkamp, J.
dc.contributor.authorDuncan, J.L.
dc.contributor.authorGettinby, G.
dc.contributor.authorMcKellar, Quintin
dc.contributor.authorPark, M.
dc.contributor.authorParkins, J.J.
dc.contributor.authorReid, S.W.J.
dc.date.accessioned2013-06-26T08:16:52Z
dc.date.available2013-06-26T08:16:52Z
dc.date.issued1997-09
dc.identifier.citationStear , M J , Bairden , K , Bishop , S C , Buitkamp , J , Duncan , J L , Gettinby , G , McKellar , Q , Park , M , Parkins , J J & Reid , S W J 1997 , ' The genetic basis of resistance to Ostertagia circumcincta in lambs ' , The Veterinary Journal , vol. 154 , no. 2 , pp. 111-119 . https://doi.org/10.1016/S1090-0233(97)80049-4
dc.identifier.otherPURE: 1422247
dc.identifier.otherPURE UUID: 7d5baad1-ec0e-490b-a3ea-4944545d7846
dc.identifier.otherBibtex: urn:c1c7fbea70acd4e26fa8e0089bd5c1c4
dc.identifier.otherScopus: 0031229646
dc.identifier.urihttp://hdl.handle.net/2299/10953
dc.description.abstractThe relationship between Ostertagia (Teladorsagia) circumcincta and sheep is one of the best understood host-parasite relationships in any species. The key components of resistance have been quantified, the extent of genetic control has been established for lambs, and methods now exist to breed lambs which will be both more resistant to worms and more productive than unselected lambs. A major gene for resistance has been identified within or around the major histocompatibility complex, and this gene appears to be the strongest yet identified for resistance to any parasite species. The most important mechanisms of resistance are local Igh responses which regulate worm fecundity and immediate hypersensitivity responses which regulate worm burdens. IgA responses develop before effective immediate hypersensitivity responses. Good simulation models now exist to predict, for example, outbreaks of disease and the response of sheep to selection. The challenge now is to use our improved understanding of the population biology to develop even better simulation models and to produce expert systems based on these models which can be used by veterinarians and others to determine optimal procedures for individual farms to control disease and reduce sub-clinical economic losses.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofThe Veterinary Journal
dc.subjectparasite
dc.subjectgenetics
dc.subjectsheep
dc.subjectimmunity
dc.subjectepidemiology
dc.titleThe genetic basis of resistance to Ostertagia circumcincta in lambsen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/S1090-0233(97)80049-4
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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