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        Noradrenergic mechanisms in the prefrontal cortex.

        Author
        Nutt, D.J.
        Lalies, M.D.
        Lione, Lisa
        Hudson, A.L.
        Attention
        2299/10958
        Abstract
        There is growing evidence that noradrenergic inputs to the prefrontal cortex (PFC) play an important role in regulating its function. This paper reviews the pharmacological control of noradrenaline (NA) release in this region, with particular reference to our studies using brain microdialysis, and also describes how NA levels are modulated by antidepressant and antipsychotic drugs. The suggestion that atypical antipsychotics such as clozapine and risperidone may produce clinical benefits by their ability to increase NA release is discussed. Finally, a new class of drugs, which show selectivity for imidazoline receptors is described. These compounds are shown to similarly increase extracellular NA in the PFC. Their potential utility as clinical treatments is discussed
        Publication date
        1997
        Published in
        Journal of Psychopharmacology
        Published version
        https://doi.org/10.1177/026988119701100209
        Other links
        http://hdl.handle.net/2299/10958
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