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dc.contributor.authorNutt, D.J.
dc.contributor.authorLalies, M.D.
dc.contributor.authorLione, Lisa
dc.contributor.authorHudson, A.L.
dc.identifier.citationNutt , D J , Lalies , M D , Lione , L & Hudson , A L 1997 , ' Noradrenergic mechanisms in the prefrontal cortex. ' , Journal of Psychopharmacology , vol. 11· , no. 2 , pp. 163-168 .
dc.identifier.otherPURE: 1491843
dc.identifier.otherPURE UUID: 257af73d-1e99-4c74-b17d-285637cc8e80
dc.identifier.otherScopus: 0030904229
dc.description.abstractThere is growing evidence that noradrenergic inputs to the prefrontal cortex (PFC) play an important role in regulating its function. This paper reviews the pharmacological control of noradrenaline (NA) release in this region, with particular reference to our studies using brain microdialysis, and also describes how NA levels are modulated by antidepressant and antipsychotic drugs. The suggestion that atypical antipsychotics such as clozapine and risperidone may produce clinical benefits by their ability to increase NA release is discussed. Finally, a new class of drugs, which show selectivity for imidazoline receptors is described. These compounds are shown to similarly increase extracellular NA in the PFC. Their potential utility as clinical treatments is discusseden
dc.relation.ispartofJournal of Psychopharmacology
dc.titleNoradrenergic mechanisms in the prefrontal cortex.en
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionCardiovascular Pathologies
dc.contributor.institutionDiabetic neuropathies
dc.contributor.institutionTRP Ion channels
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review

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