dc.contributor.author | Nutt, D.J. | |
dc.contributor.author | Lalies, M.D. | |
dc.contributor.author | Lione, Lisa | |
dc.contributor.author | Hudson, A.L. | |
dc.date.accessioned | 2013-06-26T13:31:50Z | |
dc.date.available | 2013-06-26T13:31:50Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | Nutt , D J , Lalies , M D , Lione , L & Hudson , A L 1997 , ' Noradrenergic mechanisms in the prefrontal cortex. ' , Journal of Psychopharmacology , vol. 11· , no. 2 , pp. 163-168 . https://doi.org/10.1177/026988119701100209 | |
dc.identifier.issn | 0269-8811 | |
dc.identifier.uri | http://hdl.handle.net/2299/10958 | |
dc.description.abstract | There is growing evidence that noradrenergic inputs to the prefrontal cortex (PFC) play an important role in regulating its function. This paper reviews the pharmacological control of noradrenaline (NA) release in this region, with particular reference to our studies using brain microdialysis, and also describes how NA levels are modulated by antidepressant and antipsychotic drugs. The suggestion that atypical antipsychotics such as clozapine and risperidone may produce clinical benefits by their ability to increase NA release is discussed. Finally, a new class of drugs, which show selectivity for imidazoline receptors is described. These compounds are shown to similarly increase extracellular NA in the PFC. Their potential utility as clinical treatments is discussed | en |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Psychopharmacology | |
dc.title | Noradrenergic mechanisms in the prefrontal cortex. | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | TRP Ion channels | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1177/026988119701100209 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |