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dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorCosta, S.
dc.contributor.authorAl-Bargouthy, G.
dc.contributor.authorJackson, M. J.
dc.contributor.authorZeng, Bai-Yun
dc.contributor.authorKuoppamaki, M.
dc.contributor.authorObeso, J. A.
dc.contributor.authorJenner, P.
dc.date.accessioned2013-06-27T07:31:53Z
dc.date.available2013-06-27T07:31:53Z
dc.date.issued2005-09
dc.identifier.citationIravani , M M , Costa , S , Al-Bargouthy , G , Jackson , M J , Zeng , B-Y , Kuoppamaki , M , Obeso , J A & Jenner , P 2005 , ' Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia ' , European Journal of Neuroscience , vol. 22 , no. 6 , pp. 1305-1318 . https://doi.org/10.1111/j.1460-9568.2005.04308.x
dc.identifier.issn0953-816X
dc.identifier.otherPURE: 735357
dc.identifier.otherPURE UUID: 6c25d730-522c-40da-8ced-07a5370700cc
dc.identifier.otherWOS: 000232142000005
dc.identifier.otherScopus: 26644452301
dc.identifier.otherORCID: /0000-0002-4905-9682/work/32997589
dc.identifier.urihttp://hdl.handle.net/2299/10968
dc.description.abstractPallidotomy paradoxically reduces the intensity of levodopa-induced dyskinesia without worsening motor symptoms. The reasons for this are not clear and no experimental study has investigated this phenomenon. The objective of this investigation was to evaluate the effects of unilateral pallidotomy on locomotor activity, motor disability and levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated levodopa-primed common marmosets. Animals were primed to exhibit dyskinesia by daily administration of levodopa until stable dyskinesia was evoked by each dose. Locomotor activity, motor disability and dyskinesia were assessed weekly at baseline and following an acute levodopa challenge. Prior to pallidotomies, two distinct groups of animals emerged: poor responders to levodopa with mild dyskinesia (Group 1) and those exhibiting a marked increase in motor activity and pronounced dyskinesia (Group 2). Electrolytic lesions were placed in the left internal segment of the globus pallidus. Pallidotomy had no effect on basal or levodopa-induced motor activity in either group but significantly improved basal motor disability in Group 2. Following pallidotomy, the ability of levodopa to reduce motor disability was significantly increased in both groups. Pallidotomy improved dyskinesia in both Groups 1 and 2 but it was more effective in reducing dystonia compared with chorea. The effect of pallidotomy on dyskinesia in Group 2 was transient, with the intensity of involuntary movements reverting to presurgery levels 4 weeks later. This study shows that in levodopa-primed, parkinsonian marmosets, placement of discrete globus pallidus lesions can ameliorate levodopa-induced dyskinesia but not akinesia. This model allows the evaluation of pallidotomy-induced biochemical changes in dyskinetic primates.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Neuroscience
dc.subjectdyskinesia
dc.subjectglobus pallidus
dc.subjectlevodopa
dc.subject1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
dc.subject1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
dc.subjectpallidotomy
dc.subjectADVANCED PARKINSONS-DISEASE
dc.subjectLEKSELLS POSTEROVENTRAL PALLIDOTOMY
dc.subjectPOSTERIOR GPI PALLIDOTOMY
dc.subjectBASAL GANGLIA
dc.subjectSUBTHALAMIC NUCLEUS
dc.subjectGLOBUS-PALLIDUS
dc.subjectFOLLOW-UP
dc.subjectMEDIAL PALLIDOTOMY
dc.subjectSURGICAL-TREATMENT
dc.subjectPRIMATE MODELS
dc.titleUnilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesiaen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1111/j.1460-9568.2005.04308.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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