dc.contributor.author | El Mohsen, M. M. A. | |
dc.contributor.author | Iravani, Mahmoud M. | |
dc.contributor.author | Spencer, J. P. E. | |
dc.contributor.author | Rose, S. | |
dc.contributor.author | Fahim, A. T. | |
dc.contributor.author | Motawi, T. M. K. | |
dc.contributor.author | Ismail, N. A. F. | |
dc.contributor.author | Jenner, P. | |
dc.date.accessioned | 2013-06-27T07:31:54Z | |
dc.date.available | 2013-06-27T07:31:54Z | |
dc.date.issued | 2005-10-21 | |
dc.identifier.citation | El Mohsen , M M A , Iravani , M M , Spencer , J P E , Rose , S , Fahim , A T , Motawi , T M K , Ismail , N A F & Jenner , P 2005 , ' Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants ' , Biochemical and Biophysical Research Communications , vol. 336 , no. 2 , pp. 386-391 . https://doi.org/10.1016/j.bbrc.2005.07.201 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.other | ORCID: /0000-0002-4905-9682/work/32997588 | |
dc.identifier.uri | http://hdl.handle.net/2299/10969 | |
dc.description.abstract | The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation in brain susceptibility to age-associated oxidative stress as shown by increased lipofuscin deposition and protein carbonyl levels in male rats of age 15-16 months compared to control ones (3-5 months). The hippocampus is the area most vulnerable to change compared to the cortex and cerebellum. However, proteasomal enzyme activity was not affected by age in any of the brain regions studied. Treatment with melatonin or coenzyme Q10 for 4 weeks reduced the lipofuscin content of the hippocampus and carbonyl level. However, both melatonin and coenzyme Q10 treatments inhibited beta-glutamyl peptide hydrolase activity. This suggests that these molecules can alter proteasome function independently of their antioxidant actions. (c) 2005 Elsevier Inc. All rights reserved. | en |
dc.format.extent | 6 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | |
dc.subject | oxidative stress | |
dc.subject | carbonyls | |
dc.subject | lipofuscin | |
dc.subject | proteasome | |
dc.subject | melatonin | |
dc.subject | coenzyme Q10 | |
dc.subject | LIPID-PEROXIDATION | |
dc.subject | OXIDIZED PROTEINS | |
dc.subject | COENZYME Q(10) | |
dc.subject | LIFE-SPAN | |
dc.subject | STRESS | |
dc.subject | PROTEOLYSIS | |
dc.subject | UBIQUINONE | |
dc.subject | DAMAGE | |
dc.subject | CELLS | |
dc.subject | DEGRADATION | |
dc.title | Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.bbrc.2005.07.201 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |