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dc.contributor.authorEl Mohsen, M. M. A.
dc.contributor.authorIravani, Mahmoud M.
dc.contributor.authorSpencer, J. P. E.
dc.contributor.authorRose, S.
dc.contributor.authorFahim, A. T.
dc.contributor.authorMotawi, T. M. K.
dc.contributor.authorIsmail, N. A. F.
dc.contributor.authorJenner, P.
dc.date.accessioned2013-06-27T07:31:54Z
dc.date.available2013-06-27T07:31:54Z
dc.date.issued2005-10-21
dc.identifier.citationEl Mohsen , M M A , Iravani , M M , Spencer , J P E , Rose , S , Fahim , A T , Motawi , T M K , Ismail , N A F & Jenner , P 2005 , ' Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants ' Biochemical and Biophysical Research Communications , vol. 336 , no. 2 , pp. 386-391 . https://doi.org/10.1016/j.bbrc.2005.07.201
dc.identifier.issn0006-291X
dc.identifier.otherPURE: 735427
dc.identifier.otherPURE UUID: 219627fb-9629-466c-86fa-663d2432d6f6
dc.identifier.otherWOS: 000232173200003
dc.identifier.otherScopus: 24644487045
dc.identifier.urihttp://hdl.handle.net/2299/10969
dc.description.abstractThe free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation in brain susceptibility to age-associated oxidative stress as shown by increased lipofuscin deposition and protein carbonyl levels in male rats of age 15-16 months compared to control ones (3-5 months). The hippocampus is the area most vulnerable to change compared to the cortex and cerebellum. However, proteasomal enzyme activity was not affected by age in any of the brain regions studied. Treatment with melatonin or coenzyme Q10 for 4 weeks reduced the lipofuscin content of the hippocampus and carbonyl level. However, both melatonin and coenzyme Q10 treatments inhibited beta-glutamyl peptide hydrolase activity. This suggests that these molecules can alter proteasome function independently of their antioxidant actions. (c) 2005 Elsevier Inc. All rights reserved.en
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.subjectoxidative stress
dc.subjectcarbonyls
dc.subjectlipofuscin
dc.subjectproteasome
dc.subjectmelatonin
dc.subjectcoenzyme Q10
dc.subjectLIPID-PEROXIDATION
dc.subjectOXIDIZED PROTEINS
dc.subjectCOENZYME Q(10)
dc.subjectLIFE-SPAN
dc.subjectSTRESS
dc.subjectPROTEOLYSIS
dc.subjectUBIQUINONE
dc.subjectDAMAGE
dc.subjectCELLS
dc.subjectDEGRADATION
dc.titleAge-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidantsen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionPharmacology and Clinical Science Research
dc.contributor.institutionNeurodegenerative Diseases
dc.contributor.institutionAgriculture, Veterinary and Food Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.bbrc.2005.07.201
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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