| dc.contributor.author | Herbert, R. H. | |
| dc.contributor.author | Gerhard, U. | |
| dc.contributor.author | Mortishire-Smith, R. J. | |
| dc.contributor.author | Thomas, S. R. | |
| dc.contributor.author | Hollingworth, G. | |
| dc.date.accessioned | 2013-06-27T07:46:53Z | |
| dc.date.available | 2013-06-27T07:46:53Z | |
| dc.date.issued | 2005-08 | |
| dc.identifier.citation | Herbert , R H , Gerhard , U , Mortishire-Smith , R J , Thomas , S R & Hollingworth , G 2005 , ' H-1 NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists ' , Magnetic Resonance in Chemistry , vol. 43 , no. 8 , pp. 658-661 . https://doi.org/10.1002/mrc.1604 | |
| dc.identifier.issn | 0749-1581 | |
| dc.identifier.other | PURE: 848712 | |
| dc.identifier.other | PURE UUID: 01da1a3d-affb-4dda-ab37-4662c26b6618 | |
| dc.identifier.other | WOS: 000230503900007 | |
| dc.identifier.other | Scopus: 22244466760 | |
| dc.identifier.uri | http://hdl.handle.net/2299/10971 | |
| dc.description.abstract | The binding affinities at the human NK-1 receptor of two spirocyclic compounds were found to be similar despite being epimeric at a key stereocentre. This unexpected result prompted a thorough investigation of the solution conformations of the two compounds. This revealed that a conformational switch in the tetrahydrofuran ring enabled the C-3-aryl group to be equatorial in both cases, leading to a similar juxtaposition of the aryl rings. Copyright (c) 2005 John Wiley & Sons, Ltd. | en |
| dc.format.extent | 4 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Magnetic Resonance in Chemistry | |
| dc.title | H-1 NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists | en |
| dc.contributor.institution | Department of Pharmacy | |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.contributor.institution | Health & Human Sciences Research Institute | |
| dc.contributor.institution | Medicinal and Analytical Chemistry | |
| dc.description.status | Peer reviewed | |
| rioxxterms.versionofrecord | https://doi.org/10.1002/mrc.1604 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
