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dc.contributor.authorMcAuley, William James
dc.contributor.authorChavda-Sitaram, Sonal
dc.contributor.authorMader, Kerstin
dc.contributor.authorTetteh, John
dc.contributor.authorLane, Majella
dc.contributor.authorHadgraft, Jonathan
dc.date.accessioned2013-07-03T11:47:06Z
dc.date.available2013-07-03T11:47:06Z
dc.date.issued2013-04
dc.identifier.citationMcAuley , W J , Chavda-Sitaram , S , Mader , K , Tetteh , J , Lane , M & Hadgraft , J 2013 , ' The effects of esterified solvents on the diffusion of a model compound across human skin : An ATR-FTIR spectroscopic study ' , International Journal of Pharmaceutics , vol. 447 , no. 1-2 , pp. 1-6 . https://doi.org/10.1016/j.ijpharm.2013.02.022
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 1285263
dc.identifier.otherPURE UUID: e1d7c197-16de-4531-b381-1ddb89843ba1
dc.identifier.otherScopus: 84874941949
dc.identifier.urihttp://hdl.handle.net/2299/11054
dc.description.abstractAttenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to investigate the effects of three fatty acid esters on skin permeation. Propylene glycol diperlargonate (DPPG), isopropyl myristate (IPM) and isostearyl isostearate (ISIS) were selected as pharmaceutically relevant solvents with a range of lipophilicities and cyanophenol (CNP) was used as a model drug. The resultant data were compared with that obtained when water was used as the solvent. The diffusion of CNP, DPPG and IPM across epidermis was successfully described by a Fickian model. When ISIS was used as a solvent Fickian behaviour was only obtained across isolated stratum corneum suggesting that the hydrophilic layers of the epidermis interfere with the permeation of the hydrophobic ISIS. The diffusion coefficients of CNP across epidermis in the different solvents were not significantly different. Using chemometric data analysis diffusion profiles for the solvents were deconvoluted from that of the skin and modelled. Each of these solvents was found to diffuse at a faster rate across the skin than CNP. DPPG considerably increased the concentration of CNP in the stratum corneum in comparison with the other solvents indicating strong penetration enhancer potential. In contrast IPM produced a similar CNP concentration in the stratum corneum to water with ISIS resulting in a lower CNP concentration suggesting negligible enhancement and penetration retardation effects for these two solvents respectivelyen
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.titleThe effects of esterified solvents on the diffusion of a model compound across human skin : An ATR-FTIR spectroscopic studyen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.description.statusPeer reviewed
rioxxterms.versionSMUR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ijpharm.2013.02.022
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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