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dc.contributor.authorBell, D.M.
dc.contributor.authorRichards, G.
dc.contributor.authorDhillon, S.
dc.contributor.authorOxley, J.R.
dc.contributor.authorCromarty, J.
dc.contributor.authorSander, J.W.A.S.
dc.contributor.authorPatsalos, P.N.
dc.identifier.citationBell , D M , Richards , G , Dhillon , S , Oxley , J R , Cromarty , J , Sander , J W A S & Patsalos , P N 1991 , ' A comparative pharmacokinetic study of intravenous and intramuscular midazolam in patients with epilepsy ' , Epilepsy Research , vol. 10 , no. 2-3 , pp. 183-190 .
dc.identifier.otherPURE: 1850514
dc.identifier.otherPURE UUID: 0fdf74f7-e0c9-40af-a22c-700a1b10d1b5
dc.identifier.otherScopus: 0025999567
dc.description.abstractThe pharmacokinetics of midazolam, a water soluble 1,4-benzodiazepine, has been studied in 12 patients (11 male, 1 female; age range 19-57 years) with epilepsy. All patients were taking hepatic enzyme inducing antiepileptic drugs (AEDs) on a regular basis. Midazolam (5 mg) was administered intravenously and 1 week later midazolam was administered intramuscularly, the dose used being dependent on the sedative response to the intravenous dose (10 mg, n = 2; 7 mg, n = 8; 5 mg, n = 2). Serial blood samples were collected at timed intervals for 5-7 h. After intravenous administration initial distribution was rapid with a mean half-life (t 1/2 /α) of 0.06 ± 0.03 h followed by a terminal half-life (t 1/2 β or γ) of 1.5 ± 0.3 h. Volume of distribution was 0.62 ± 0.27 l/kg. After intramuscular administration midazolam was rapidly absorbed with peak serum concentrations achieved at 25 ± 23 min. Two patients showed delayed absorption. Mean terminal half-life was 2.8 ± 1.7 h. The absolute bioavailability of intramuscular midazolam was calculated in 11 patients as 87 ± 18%.en
dc.relation.ispartofEpilepsy Research
dc.titleA comparative pharmacokinetic study of intravenous and intramuscular midazolam in patients with epilepsyen
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionPatient and Medicines Safety
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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