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dc.contributor.authorHorspool, L. J.
dc.contributor.authorMcKellar, Quintin
dc.identifier.citationHorspool , L J & McKellar , Q 1995 , ' Disposition of penicillin G sodium following intravenous and oral administration to Equidae ' , The British veterinary journal , vol. 151 , no. 4 , pp. 401-12 .
dc.identifier.otherPURE: 1431673
dc.identifier.otherPURE UUID: 20fbe5d0-31e2-43ad-9dde-8e700a63fcb9
dc.identifier.otherPubMed: 7552196
dc.identifier.otherScopus: 0029339701
dc.description.abstractThe present study was designed to determine and compare the plasma disposition and pharmacokinetics of penicillin G sodium following intravenous (i.v.) administration to horses, ponies and donkeys. The plasma disposition and pharmacokinetics of penicillin G was similar in horses, ponies and donkeys (elimination half-lives--39.0, 27.3 and 31.5 min, respectively) and a dosage interval of 6-8 h would be suitable to treat infections caused by susceptible bacteria. Although penicillin G was absorbed rapidly following nasogastric administration, the systemic availability was low (0.12-0.34%), therefore oral administration would be unsuitable for systemic antimicrobial therapy in the equine. The elimination of penicillin G into the gastrointestinal tract following i.v. administration and the absorption of penicillin G from the gastrointestinal tract following oral administration were studied in two ponies with cannulated caecal fistulas. A low concentration of penicillin G (<or = 0.6 micrograms ml-1) was measured in caecal liquor following i.v. administration, however the risk of development of antimicrobial-associated colitis would be high following oral administration of penicillin G since high concentrations of drug (4.96-157.12 micrograms ml-1) were measured in caecal liquor.en
dc.relation.ispartofThe British veterinary journal
dc.subjectPenicillin G
dc.subjectcaecal fluid
dc.titleDisposition of penicillin G sodium following intravenous and oral administration to Equidaeen
dc.contributor.institutionOffice of the Vice-Chancellor
dc.contributor.institutionVeterinary Science
dc.contributor.institutionGeography, Environment and Agriculture
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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